ATF7IP explained

Activating transcription factor 7-interacting protein 1 is a protein that in humans is encoded by the ATF7IP gene.^{[1] [2] [3]}

Interactions

ATF7IP has been shown to interact with MBD1.^[4] In mice with T cell-specific deletion of Atf7ip, the protein has been shown to play a role in regulating T helper 17 cell (Th17) differentiation due to increased IL-2 production upon stimulation of the T cell receptor (TCR). This TCR stimulation occurs through deposition of H3K9me3, a repressive histone mark.^{[5] [6]}

Further reading

• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . etal. 2002PNAS...9916899M . free .
• Yamada K, Kawata H, Shou Z . Analysis of zinc-fingers and homeoboxes (ZHX)-1-interacting proteins: molecular cloning and characterization of a member of the ZHX family, ZHX3 . Biochem. J. . 373 . Pt 1 . 167–78 . 2003 . 12659632 . 10.1042/BJ20021866 . 1223464 . etal.
• Fujita N, Watanabe S, Ichimura T . MCAF Mediates MBD1-Dependent Transcriptional Repression . Mol. Cell. Biol. . 23 . 8 . 2834–43 . 2003 . 12665582 . 10.1128/MCB.23.8.2834-2843.2003 . 152570 . etal.
• Morris JA, Kandpal G, Ma L, Austin CP . DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation . Hum. Mol. Genet. . 12 . 13 . 1591–608 . 2004 . 12812986 . 10.1093/hmg/ddg162 .
• Wang H, An W, Cao R . mAM facilitates conversion by ESET of dimethyl to trimethyl lysine 9 of histone H3 to cause transcriptional repression . Mol. Cell . 12 . 2 . 475–87 . 2003 . 14536086 . 10.1016/j.molcel.2003.08.007 . etal. free .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Colland F, Jacq X, Trouplin V . Functional Proteomics Mapping of a Human Signaling Pathway . Genome Res. . 14 . 7 . 1324–32 . 2004 . 15231748 . 10.1101/gr.2334104 . 442148 . etal.
• Gerhard DS, Wagner L, Feingold EA . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Ichimura T, Watanabe S, Sakamoto Y . Transcriptional repression and heterochromatin formation by MBD1 and MCAF/AM family proteins . J. Biol. Chem. . 280 . 14 . 13928–35 . 2005 . 15691849 . 10.1074/jbc.M413654200 . etal. free .
• Chang LK, Chung JY, Hong YR . Activation of Sp1-mediated transcription by Rta of Epstein–Barr virus via an interaction with MCAF1 . Nucleic Acids Res. . 33 . 20 . 6528–39 . 2005 . 16314315 . 10.1093/nar/gki956 . 1298921 . etal.
• Uchimura Y, Ichimura T, Uwada J . Involvement of SUMO modification in MBD1- and MCAF1-mediated heterochromatin formation . J. Biol. Chem. . 281 . 32 . 23180–90 . 2006 . 16757475 . 10.1074/jbc.M602280200 . etal. free.
• Olsen JV, Blagoev B, Gnad F . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . etal. free .

External links

• • PDBe-KB provides an overview of all the structure information available in the PDB for Human Activating transcription factor 7-interacting protein 1 (ATF7IP)

Notes and References

1. Gunther M, Laithier M, Brison O . A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening . Mol Cell Biochem . 210 . 1–2 . 131–42 . Dec 2000 . 10976766 . 10.1023/A:1007177623283 . 1339642 .
2. De Graeve F, Bahr A, Chatton B, Kedinger C . A murine ATFa-associated factor with transcriptional repressing activity . Oncogene . 19 . 14 . 1807–19 . Jun 2000 . 10777215 . 10.1038/sj.onc.1203492 . 22900736 .
3. Web site: Entrez Gene: ATF7IP activating transcription factor 7 interacting protein.
4. Fujita . Naoyuki . Watanabe Sugiko . Ichimura Takaya . Ohkuma Yoshiaki . Chiba Tsutomu . Saya Hideyuki . Nakao Mitsuyoshi . Apr 2003 . MCAF Mediates MBD1-Dependent Transcriptional Repression . Mol. Cell. Biol. . 23 . 8 . 2834–43 . United States. 0270-7306. 12665582 . 10.1128/MCB.23.8.2834-2843.2003 . 152570 .
5. Sin . Jun Hyung . Zuckerman . Cassandra . Cortez . Jessica T. . Eckalbar . Walter L. . Erle . David J. . Anderson . Mark S. . Waterfield . Michael R. . 2019-09-02 . The epigenetic regulator ATF7ip inhibits Il2 expression, regulating Th17 responses . The Journal of Experimental Medicine . 216 . 9 . 2024–2037 . 10.1084/jem.20182316 . 1540-9538 . 6719416 . 31217192.
6. Zhao . Zhipeng . Feng . Lu . Peng . Xuerun . Ma . Tingnan . Tong . Rongsheng . Zhong . Lei . 2022 . Role of histone methyltransferase SETDB1 in regulation of tumourigenesis and immune response . Frontiers in Pharmacology . 13 . 1073713 . 10.3389/fphar.2022.1073713 . 1663-9812 . 9793902 . 36582533 . free .