ATF7 explained
Cyclic AMP-dependent transcription factor ATF-7 is a protein that in humans is encoded by the ATF7 gene.[1] [2] [3]
Homonym
In 2001, Peters et al. published a paper showing that ATF-7, a Novel bZIP Protein, interacts with PTP4A1.This ATF-7 is actually ATF5 and not ATF7, as noted by the authors at the end of their paper ("Note Added in Proof—While this manuscript was under review, sequences for mouse and human ATF-5 were deposited in GenBankTM. It appears that ATF-7 and ATF-5 are likely to be the same protein. In addition, an unrelated sequence named ATF7 has also been deposited in GenBankTM. In order to avoid confusion, future work on the protein described in this publication will likely refer to it as either ATF-5 or ATF-5/7.")[2]
Further reading
- Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .
- Hamard PJ, Dalbies-Tran R, Hauss C, Davidson I, Kedinger C, Chatton B . A functional interaction between ATF7 and TAF12 that is modulated by TAF4 . Oncogene . 24 . 21 . 3472–83 . 2005 . 15735663 . 10.1038/sj.onc.1208565 . 23431610 .
- Hamard PJ, Boyer-Guittaut M, Camuzeaux B, Dujardin D, Hauss C, Oelgeschläger T, Vigneron M, Kedinger C, Chatton B . Sumoylation delays the ATF7 transcription factor subcellular localization and inhibits its transcriptional activity . Nucleic Acids Res. . 35 . 4 . 1134–44 . 2007 . 17264123 . 1851647 . 10.1093/nar/gkl1168 .
- Breitwieser W, Lyons S, Flenniken AM, Ashton G, Bruder G, Willington M, Lacaud G, Kouskoff V, Jones N . Feedback regulation of p38 activity via ATF2 is essential for survival of embryonic liver cells . Genes Dev. . 21 . 16 . 2069–82 . 2007 . 17699753 . 1948861 . 10.1101/gad.430207 .
- Newman JR, Keating AE . Comprehensive identification of human bZIP interactions with coiled-coil arrays . Science . 300 . 5628 . 2097–101 . 2003 . 12805554 . 10.1126/science.1084648 . 2003Sci...300.2097N . 36715183 . free .
- Newman SP, Bates NP, Vernimmen D, Parker MG, Hurst HC . Cofactor competition between the ligand-bound oestrogen receptor and an intron 1 enhancer leads to oestrogen repression of ERBB2 expression in breast cancer . Oncogene . 19 . 4 . 490–7 . 2000 . 10698518 . 10.1038/sj.onc.1203416 . 7619430 .
- Goetz J, Chatton B, Mattei MG, Kedinger C . Structure and expression of the ATFa gene . J. Biol. Chem. . 271 . 47 . 29589–98 . 1997 . 8939888 . 10.1074/jbc.271.47.29589 . free .
- Bocco JL, Bahr A, Goetz J, Hauss C, Kallunki T, Kedinger C, Chatton B . In vivo association of ATFa with JNK/SAP kinase activities . Oncogene . 12 . 9 . 1971–80 . 1996 . 8649858 .
- Pescini R, Kaszubska W, Whelan J, DeLamarter JF, Hooft van Huijsduijnen R . ATF-a0, a novel variant of the ATF/CREB transcription factor family, forms a dominant transcription inhibitor in ATF-a heterodimers . J. Biol. Chem. . 269 . 2 . 1159–65 . 1994 . 10.1016/S0021-9258(17)42236-8 . 8288576 . free .
- Zhou Q, Gedrich RW, Engel DA . Transcriptional repression of the c-fos gene by YY1 is mediated by a direct interaction with ATF/CREB . J. Virol. . 69 . 7 . 4323–30 . 1995 . 7769693 . 189172 . 10.1128/JVI.69.7.4323-4330.1995.
Notes and References
- Gaire M, Chatton B, Kedinger C . Isolation and characterization of two novel, closely related ATF cDNA clones from HeLa cells . Nucleic Acids Res . 18 . 12 . 3467–73 . Aug 1990 . 1694576 . 330998 . 10.1093/nar/18.12.3467 .
- Peters CS, Liang X, Li S, Kannan S, Peng Y, Taub R, Diamond RH . ATF-7, a novel bZIP protein, interacts with the PRL-1 protein-tyrosine phosphatase . J Biol Chem . 276 . 17 . 13718–26 . Apr 2001 . 11278933 . 10.1074/jbc.M011562200 . free .
- Web site: Entrez Gene: ATF7 activating transcription factor 7.
