AT-121 explained

Iupac Name:	3-oxo-1'-(4-propan-2-ylcyclohexyl)-2-[2-(sulfamoylamino)ethyl]spiro[1H-isoquinoline-4,4'-piperidine]
Legal Status:	Investigational
Cas Number:	2099681-31-7
Pubchem:	129188444
C:	24
H:	38
N:	4
O:	3
S:	1
Smiles:	CC(C)[C@H]1CC[C@H](CC1)N1CCC2(CC1)C(=O)N(CCNS(N)(=O)=O)CC1=CC=CC=C21

AT-121 is an experimental analgesic. It was designed to be bifunctional, acting as an agonist at both the μ-opioid receptor and the nociceptin receptor.^[1] The interaction with the nociceptin receptor is expected to block the abuse and dependence-related side effects that are typical of opioids.^[2] A study in nonhuman primates found that AT-121 has morphine-like analgesic effects, but suppressed the addictive effects.^{[1] [3]}

See also

• AT-076
• Cebranopadol
• Oliceridine
• PZM21

Notes and References

1. Ding H, Kiguchi N, Yasuda D, Daga PR, Polgar WE, Lu JJ, Czoty PW, Kishioka S, Zaveri NT, Ko MC . 6 . A bifunctional nociceptin and mu opioid receptor agonist is analgesic without opioid side effects in nonhuman primates . Science Translational Medicine . 10 . 456 . eaar3483 . August 2018 . 30158150 . 6295194 . 10.1126/scitranslmed.aar3483 .
2. News: Scientists take big step toward finding non-addictive painkiller . August 29, 2018 . Science Daily.
3. News: Study: Non-addictive painkiller is safe, effective in animals . August 30, 2018 . UPI.