ASH2L explained

Set1/Ash2 histone methyltransferase complex subunit ASH2 is an enzyme that in humans is encoded by the ASH2L gene.^{[1] [2]}

Interactions

ASH2L has been shown to interact with MLL.^[3]

Further reading

• Wang J, Zhou Y, Yin B, Du G, Huang X, Li G, Shen Y, Yuan J, Qiang B . ASH2L: alternative splicing and downregulation during induced megakaryocytic differentiation of multipotential leukemia cell lines . J. Mol. Med. . 79 . 7 . 399–405 . 2001 . 11466562 . 10.1007/s001090100222 . 6719550 .
• Goo YH, Sohn YC, Kim DH, Kim SW, Kang MJ, Jung DJ, Kwak E, Barlev NA, Berger SL, Chow VT, Roeder RG, Azorsa DO, Meltzer PS, Suh PG, Song EJ, Lee KJ, Lee YC, Lee JW . Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins . Mol. Cell. Biol. . 23 . 1 . 140–9 . 2003 . 12482968 . 140670 . 10.1128/MCB.23.1.140-149.2003 .
• Wysocka J, Myers MP, Laherty CD, Eisenman RN, Herr W . Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1 . Genes Dev. . 17 . 7 . 896–911 . 2003 . 12670868 . 196026 . 10.1101/gad.252103 .
• Hughes CM, Rozenblatt-Rosen O, Milne TA, Copeland TD, Levine SS, Lee JC, Hayes DN, Shanmugam KS, Bhattacharjee A, Biondi CA, Kay GF, Hayward NK, Hess JL, Meyerson M . Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus . Mol. Cell . 13 . 4 . 587–97 . 2004 . 14992727 . 10.1016/S1097-2765(04)00081-4 . free .
• Yokoyama A, Wang Z, Wysocka J, Sanyal M, Aufiero DJ, Kitabayashi I, Herr W, Cleary ML . Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression . Mol. Cell. Biol. . 24 . 13 . 5639–49 . 2004 . 15199122 . 480881 . 10.1128/MCB.24.13.5639-5649.2004 .
• Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM . Functional proteomics mapping of a human signaling pathway . Genome Res. . 14 . 7 . 1324–32 . 2004 . 15231748 . 442148 . 10.1101/gr.2334104 .
• Barrios-Rodiles M, Brown KR, Ozdamar B, Bose R, Liu Z, Donovan RS, Shinjo F, Liu Y, Dembowy J, Taylor IW, Luga V, Przulj N, Robinson M, Suzuki H, Hayashizaki Y, Jurisica I, Wrana JL . High-throughput mapping of a dynamic signaling network in mammalian cells . Science . 307 . 5715 . 1621–5 . 2005 . 15761153 . 10.1126/science.1105776 . 2005Sci...307.1621B . 39457788 .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Steward MM, Lee JS, O'Donovan A, Wyatt M, Bernstein BE, Shilatifard A . Molecular regulation of H3K4 trimethylation by ASH2L, a shared subunit of MLL complexes . Nat. Struct. Mol. Biol. . 13 . 9 . 852–4 . 2006 . 16892064 . 10.1038/nsmb1131 . 19384238 .

Notes and References

1. Ikegawa S, Isomura M, Koshizuka Y, Nakamura Y . Cloning and characterization of ASH2L and Ash2l, human and mouse homologs of the Drosophila ash2 gene . Cytogenet. Cell Genet. . 84 . 3–4 . 167–72 . Jul 1999 . 10393421 . 10.1159/000015248 . 19257499 .
2. Web site: Entrez Gene: ASH2L ash2 (absent, small, or homeotic)-like (Drosophila).
3. Yokoyama A, Wang Z, Wysocka J, Sanyal M, Aufiero DJ, Kitabayashi I, Herr W, Cleary ML . Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression . Mol. Cell. Biol. . 24 . 13 . 5639–49 . Jul 2004 . 15199122 . 480881 . 10.1128/MCB.24.13.5639-5649.2004 .