ASF1B explained

Histone chaperone ASF1B is a protein that in humans is encoded by the ASF1B gene.^{[1] [2] [3]}

Function

This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The encoded protein is the substrate of the tousled-like kinase family of cell cycle-regulated kinases, and may play a key role in modulating the nucleosome structure of chromatin by ensuring a constant supply of histones at sites of nucleosome assembly.^[3]

Interactions

ASF1B has been shown to interact with TLK2,^[4] CHAF1B,^{[1] [4]} TLK1^{[2] [4]} and CHAF1A.^{[1] [4]}

Further reading

• Loyola A, Almouzni G . Histone chaperones, a supporting role in the limelight . Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression . 1677 . 1–3 . 3–11 . Mar 2004 . 15020040 . 10.1016/j.bbaexp.2003.09.012 .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . Jan 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . Oct 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Umehara T, Horikoshi M . Transcription initiation factor IID-interactive histone chaperone CIA-II implicated in mammalian spermatogenesis . The Journal of Biological Chemistry . 278 . 37 . 35660–7 . Sep 2003 . 12842904 . 10.1074/jbc.M303549200 . free .
• Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW . Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation . Nature Biotechnology . 22 . 6 . 707–16 . Jun 2004 . 15146197 . 10.1038/nbt971 . 27764390 .
• Groth A, Ray-Gallet D, Quivy JP, Lukas J, Bartek J, Almouzni G . Human Asf1 regulates the flow of S phase histones during replicational stress . Molecular Cell . 17 . 2 . 301–11 . Jan 2005 . 15664198 . 10.1016/j.molcel.2004.12.018 . free .
• Sen SP, De Benedetti A . TLK1B promotes repair of UV-damaged DNA through chromatin remodeling by Asf1 . BMC Molecular Biology . 7 . 37 . 2006 . 17054786 . 1626478 . 10.1186/1471-2199-7-37 . free .
• Hayashi R, Goto Y, Tanaka R, Oonogi K, Hisasue M, Yoshida K . Transcriptional regulation of human chromatin assembly factor ASF1 . DNA and Cell Biology . 26 . 2 . 91–9 . Feb 2007 . 17328667 . 10.1089/dna.2006.0515 .
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D . Large-scale mapping of human protein-protein interactions by mass spectrometry . Molecular Systems Biology . 3 . 1 . 89 . 2007 . 17353931 . 1847948 . 10.1038/msb4100134 .

Notes and References

1. Mello JA, Silljé HH, Roche DM, Kirschner DB, Nigg EA, Almouzni G . Human Asf1 and CAF-1 interact and synergize in a repair-coupled nucleosome assembly pathway . EMBO Reports . 3 . 4 . 329–34 . Apr 2002 . 11897662 . 1084056 . 10.1093/embo-reports/kvf068 .
2. Silljé HH, Nigg EA . Identification of human Asf1 chromatin assembly factors as substrates of Tousled-like kinases . Current Biology . 11 . 13 . 1068–73 . Jul 2001 . 11470414 . 10.1016/S0960-9822(01)00298-6 . 8866062 . free . 2001CBio...11.1068S .
3. Web site: Entrez Gene: ASF1B ASF1 anti-silencing function 1 homolog B (S. cerevisiae).
4. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D . Large-scale mapping of human protein-protein interactions by mass spectrometry . Molecular Systems Biology . 3 . 1 . 89 . 2007 . 17353931 . 1847948 . 10.1038/msb4100134 .