ASF1A explained

Histone chaperone ASF1A is a protein that in humans is encoded by the ASF1A gene.^{[1] [2] [3]}

Function

This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The protein is a key component of a histone donor complex that functions in nucleosome assembly. It interacts with histones H3 and H4, and functions together with a chromatin assembly factor during DNA replication and repair.

Interactions

ASF1A has been shown to interact with TLK1,^{[4] [5]} TLK2,^[4] CHAF1B^[6] and CHAF1A.^[6]

Further reading

• Munakata T, Adachi N, Yokoyama N, Kuzuhara T, Horikoshi M . A human homologue of yeast anti-silencing factor has histone chaperone activity . Genes to Cells . 5 . 3 . 221–33 . Mar 2000 . 10759893 . 10.1046/j.1365-2443.2000.00319.x . 20198031 . free .
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A . Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs . Genome Research . 11 . 3 . 422–35 . Mar 2001 . 11230166 . 311072 . 10.1101/gr.GR1547R .
• Silljé HH, Nigg EA . Identification of human Asf1 chromatin assembly factors as substrates of Tousled-like kinases . Current Biology . 11 . 13 . 1068–73 . Jul 2001 . 11470414 . 10.1016/S0960-9822(01)00298-6 . 8866062 . free . 2001CBio...11.1068S .
• Mello JA, Silljé HH, Roche DM, Kirschner DB, Nigg EA, Almouzni G . Human Asf1 and CAF-1 interact and synergize in a repair-coupled nucleosome assembly pathway . EMBO Reports . 3 . 4 . 329–34 . Apr 2002 . 11897662 . 1084056 . 10.1093/embo-reports/kvf068 .
• Chimura T, Kuzuhara T, Horikoshi M . Identification and characterization of CIA/ASF1 as an interactor of bromodomains associated with TFIID . Proceedings of the National Academy of Sciences of the United States of America . 99 . 14 . 9334–9 . Jul 2002 . 12093919 . 123141 . 10.1073/pnas.142627899 . 2002PNAS...99.9334C . free .
• Umehara T, Horikoshi M . Transcription initiation factor IID-interactive histone chaperone CIA-II implicated in mammalian spermatogenesis . The Journal of Biological Chemistry . 278 . 37 . 35660–7 . Sep 2003 . 12842904 . 10.1074/jbc.M303549200 . free .
• Tagami H, Ray-Gallet D, Almouzni G, Nakatani Y . Histone H3.1 and H3.3 complexes mediate nucleosome assembly pathways dependent or independent of DNA synthesis . Cell . 116 . 1 . 51–61 . Jan 2004 . 14718166 . 10.1016/S0092-8674(03)01064-X . 13262868 . free .
• Mousson F, Couprie J, Thuret JY, Neumann JM, Mann C, Ochsenbein F . 1H, 13C and 15N resonance assignments of the conserved core of hAsf1 A . Journal of Biomolecular NMR . 29 . 3 . 413–4 . Jul 2004 . 15213445 . 10.1023/B:JNMR.0000032497.24661.44 . 33782636 .
• Zhang R, Poustovoitov MV, Ye X, Santos HA, Chen W, Daganzo SM, Erzberger JP, Serebriiskii IG, Canutescu AA, Dunbrack RL, Pehrson JR, Berger JM, Kaufman PD, Adams PD . Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA . Developmental Cell . 8 . 1 . 19–30 . Jan 2005 . 15621527 . 10.1016/j.devcel.2004.10.019 . free .
• Groth A, Ray-Gallet D, Quivy JP, Lukas J, Bartek J, Almouzni G . Human Asf1 regulates the flow of S phase histones during replicational stress . Molecular Cell . 17 . 2 . 301–11 . Jan 2005 . 15664198 . 10.1016/j.molcel.2004.12.018 . free .
• Mousson F, Lautrette A, Thuret JY, Agez M, Courbeyrette R, Amigues B, Becker E, Neumann JM, Guerois R, Mann C, Ochsenbein F . Structural basis for the interaction of Asf1 with histone H3 and its functional implications . Proceedings of the National Academy of Sciences of the United States of America . 102 . 17 . 5975–80 . Apr 2005 . 15840725 . 1087920 . 10.1073/pnas.0500149102 . 2005PNAS..102.5975M . free .
• Tang Y, Poustovoitov MV, Zhao K, Garfinkel M, Canutescu A, Dunbrack R, Adams PD, Marmorstein R . Structure of a human ASF1a-HIRA complex and insights into specificity of histone chaperone complex assembly . Nature Structural & Molecular Biology . 13 . 10 . 921–9 . Oct 2006 . 16980972 . 2933817 . 10.1038/nsmb1147 .
• Sen SP, De Benedetti A . TLK1B promotes repair of UV-damaged DNA through chromatin remodeling by Asf1 . BMC Molecular Biology . 7 . 37 . 2006 . 17054786 . 1626478 . 10.1186/1471-2199-7-37 . free .
• Agez M, Chen J, Guerois R, van Heijenoort C, Thuret JY, Mann C, Ochsenbein F . Structure of the histone chaperone ASF1 bound to the histone H3 C-terminal helix and functional insights . Structure . 15 . 2 . 191–9 . Feb 2007 . 17292837 . 10.1016/j.str.2007.01.002 . free .
• Natsume R, Eitoku M, Akai Y, Sano N, Horikoshi M, Senda T . Structure and function of the histone chaperone CIA/ASF1 complexed with histones H3 and H4 . Nature . 446 . 7133 . 338–41 . Mar 2007 . 17293877 . 10.1038/nature05613 . 2007Natur.446..338N . 4410753 .

Notes and References

1. Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W . Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics . Genome Research . 10 . 5 . 703–13 . May 2000 . 10810093 . 310876 . 10.1101/gr.10.5.703 .
2. Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z . Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells . Genome Research . 10 . 10 . 1546–60 . Oct 2000 . 11042152 . 310934 . 10.1101/gr.140200 .
3. Web site: Entrez Gene: ASF1A ASF1 anti-silencing function 1 homolog A (S. cerevisiae).
4. Silljé HH, Nigg EA . Identification of human Asf1 chromatin assembly factors as substrates of Tousled-like kinases . Current Biology . 11 . 13 . 1068–73 . Jul 2001 . 11470414 . 10.1016/S0960-9822(01)00298-6 . 8866062 . free . 2001CBio...11.1068S .
5. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . Oct 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
6. Mello JA, Silljé HH, Roche DM, Kirschner DB, Nigg EA, Almouzni G . Human Asf1 and CAF-1 interact and synergize in a repair-coupled nucleosome assembly pathway . EMBO Reports . 3 . 4 . 329–34 . Apr 2002 . 11897662 . 1084056 . 10.1093/embo-reports/kvf068 .