ASB3 explained

Ankyrin repeat and SOCS box protein 3 is a protein that in humans is encoded by the ASB3 gene.^{[1] [2]}

The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Multiple alternatively spliced transcript variants have been described for this gene but some of the full length sequences are not known.^[2]

Further reading

• Kile BT, Schulman BA, Alexander WS . The SOCS box: a tale of destruction and degradation. . Trends Biochem. Sci. . 27 . 5 . 235–41 . 2002 . 12076535 . 10.1016/S0968-0004(02)02085-6 . etal.
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 . etal.
• Kile BT, Viney EM, Willson TA . Cloning and characterization of the genes encoding the ankyrin repeat and SOCS box-containing proteins Asb-1, Asb-2, Asb-3 and Asb-4. . Gene . 258 . 1–2 . 31–41 . 2001 . 11111040 . 10.1016/S0378-1119(00)00402-9 . etal.
• Kile BT, Metcalf D, Mifsud S . Functional analysis of Asb-1 using genetic modification in mice. . Mol. Cell. Biol. . 21 . 18 . 6189–97 . 2001 . 11509662 . 10.1128/MCB.21.18.6189-6197.2001 . 87336 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Ewing RM, Chu P, Elisma F . Large-scale mapping of human protein-protein interactions by mass spectrometry. . Mol. Syst. Biol. . 3 . 1. 89 . 2007 . 17353931 . 10.1038/msb4100134 . 1847948 . etal.

Notes and References

1. Chung AS, Guan YJ, Yuan ZL, Albina JE, Chin YE . Ankyrin repeat and SOCS box 3 (ASB3) mediates ubiquitination and degradation of tumor necrosis factor receptor II . Mol Cell Biol . 25 . 11 . 4716–26 . May 2005 . 15899873 . 1140645 . 10.1128/MCB.25.11.4716-4726.2005 .
2. Web site: Entrez Gene: ASB3 ankyrin repeat and SOCS box-containing 3.