ASB2 explained

Ankyrin repeat and SOCS box protein 2 (ASBS) is a protein that is encoded by the ASB2 gene in humans.^[1]

The ASB2 protein belongs to the ankyrin repeat and SOCS box-containing (ASB) family of proteins. It consists of an ankyrin repeat sequence and a SOCS box domain. The SOCS box plays a role in connecting suppressor of cytokine signaling (SOCS) proteins and their binding partners with the elongin B and C complex, potentially facilitating their degradation. This gene is induced by all-trans retinoic acid. In myeloid leukemia cells, the expression of this encoded protein has been shown to induce growth inhibition and chromatin condensation. Multiple alternatively spliced transcript variants have been described for this gene but their full length sequences are not known.^[1]

Further reading

• Kile BT, Schulman BA, Alexander WS . The SOCS box: a tale of destruction and degradation. . Trends Biochem. Sci. . 27 . 5 . 235–41 . 2002 . 12076535 . 10.1016/S0968-0004(02)02085-6 . etal.
• Hilton DJ, Richardson RT, Alexander WS . Twenty proteins containing a C-terminal SOCS box form five structural classes. . Proc. Natl. Acad. Sci. U.S.A. . 95 . 1 . 114–9 . 1998 . 9419338 . 10.1073/pnas.95.1.114 . 18144 . 1998PNAS...95..114H . etal. free .
• Kile BT, Viney EM, Willson TA . Cloning and characterization of the genes encoding the ankyrin repeat and SOCS box-containing proteins Asb-1, Asb-2, Asb-3 and Asb-4. . Gene . 258 . 1–2 . 31–41 . 2001 . 11111040 . 10.1016/S0378-1119(00)00402-9 . etal.
• Kile BT, Metcalf D, Mifsud S . Functional analysis of Asb-1 using genetic modification in mice . Mol. Cell. Biol. . 21 . 18 . 6189–97 . 2001 . 11509662 . 10.1128/MCB.21.18.6189-6197.2001 . 87336 . etal.
• Kohroki J, Fujita S, Itoh N . ATRA-regulated Asb-2 gene induced in differentiation of HL-60 leukemia cells . FEBS Lett. . 505 . 2 . 223–8 . 2001 . 11566180 . 10.1016/S0014-5793(01)02829-0 . etal. free .
• Guibal FC, Moog-Lutz C, Smolewski P . ASB-2 inhibits growth and promotes commitment in myeloid leukemia cells . J. Biol. Chem. . 277 . 1 . 218–24 . 2002 . 11682484 . 10.1074/jbc.M108476200 . etal. free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Namciu SJ, Friedman RD, Marsden MD . Sequence organization and matrix attachment regions of the human serine protease inhibitor gene cluster at 14q32.1 . Mamm. Genome . 15 . 3 . 162–78 . 2004 . 15014966 . 10.1007/s00335-003-2311-y . 8594824 . etal.
• Colland F, Jacq X, Trouplin V . Functional proteomics mapping of a human signaling pathway . Genome Res. . 14 . 7 . 1324–32 . 2004 . 15231748 . 10.1101/gr.2334104 . 442148 . etal.
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Heuzé ML, Guibal FC, Banks CA . ASB2 is an Elongin BC-interacting protein that can assemble with Cullin 5 and Rbx1 to reconstitute an E3 ubiquitin ligase complex . J. Biol. Chem. . 280 . 7 . 5468–74 . 2005 . 15590664 . 10.1074/jbc.M413040200 . etal. free .
• Rual JF, Venkatesan K, Hao T . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 . etal.
• Kohroki J, Nishiyama T, Nakamura T, Masuho Y . ASB proteins interact with Cullin5 and Rbx2 to form E3 ubiquitin ligase complexes . FEBS Lett. . 579 . 30 . 6796–802 . 2006 . 16325183 . 10.1016/j.febslet.2005.11.016 . 7196353 . free .

Notes and References

1. Web site: Entrez Gene: ASB2 ankyrin repeat and SOCS box-containing 2.