ASB1 explained

Ankyrin repeat and SOCS box protein 1 is a protein that is in humans, encoded by the ASB1 gene.^[1]

The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation.

Further reading

• Kile BT, Schulman BA, Alexander WS . The SOCS box: a tale of destruction and degradation . Trends Biochem. Sci. . 27 . 5 . 235–41 . 2002 . 12076535 . 10.1016/S0968-0004(02)02085-6 . etal.
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Kile BT, Metcalf D, Mifsud S . Functional analysis of Asb-1 using genetic modification in mice . Mol. Cell. Biol. . 21 . 18 . 6189–97 . 2001 . 11509662 . 10.1128/MCB.21.18.6189-6197.2001 . 87336 . etal.
• Kile BT, Viney EM, Willson TA . Cloning and characterization of the genes encoding the ankyrin repeat and SOCS box-containing proteins Asb-1, Asb-2, Asb-3 and Asb-4 . Gene . 258 . 1–2 . 31–41 . 2001 . 11111040 . 10.1016/S0378-1119(00)00402-9 . etal.
• Hirosawa M, Nagase T, Ishikawa K . Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain . DNA Res. . 6 . 5 . 329–36 . 2000 . 10574461 . 10.1093/dnares/6.5.329 . etal. free .
• Yu W, Andersson B, Worley KC . Large-scale concatenation cDNA sequencing . Genome Res. . 7 . 4 . 353–8 . 1997 . 9110174 . 10.1101/gr.7.4.353. 139146 . etal.
• Andersson B, Wentland MA, Ricafrente JY . A "double adaptor" method for improved shotgun library construction . Anal. Biochem. . 236 . 1 . 107–13 . 1996 . 8619474 . 10.1006/abio.1996.0138 . etal.

Notes and References

1. Web site: Entrez Gene: ASB1 ankyrin repeat and SOCS box-containing 1.