ASAHL explained
N-acylethanolamine-hydrolyzing acid amidase is an enzyme that in humans is encoded by the NAAA gene.[1] [2] [3]
Function
This gene encodes an N-acylethanolamine-hydrolyzing enzyme which is highly similar to acid ceramidase. Multiple transcript variants encoding different isoforms have been found for this gene.[3]
Further reading
- Schulze H, Schepers U, Sandhoff K . Overexpression and mass spectrometry analysis of mature human acid ceramidase. . Biol. Chem. . 388 . 12 . 1333–43 . 2008 . 18020949 . 10.1515/BC.2007.152 . 12612022 .
- Zhao LY, Tsuboi K, Okamoto Y . Proteolytic activation and glycosylation of N-acylethanolamine-hydrolyzing acid amidase, a lysosomal enzyme involved in the endocannabinoid metabolism. . Biochim. Biophys. Acta . 1771 . 11 . 1397–405 . 2008 . 17980170 . 10.1016/j.bbalip.2007.10.002 . etal.
- Oh JH, Yang JO, Hahn Y . Transcriptome analysis of human gastric cancer. . Mamm. Genome . 16 . 12 . 942–54 . 2006 . 16341674 . 10.1007/s00335-005-0075-2 . 69278 . etal.
- Tsuboi K, Sun YX, Okamoto Y . Molecular characterization of N-acylethanolamine-hydrolyzing acid amidase, a novel member of the choloylglycine hydrolase family with structural and functional similarity to acid ceramidase. . J. Biol. Chem. . 280 . 12 . 11082–92 . 2005 . 15655246 . 10.1074/jbc.M413473200 . etal. free .
- Huang Y, Tanimukai H, Liu F . Elevation of the level and activity of acid ceramidase in Alzheimer's disease brain. . Eur. J. Neurosci. . 20 . 12 . 3489–97 . 2005 . 15610181 . 10.1111/j.1460-9568.2004.03852.x . 11515970 . etal.
- Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
- Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
- Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery. . Genome Res. . 6 . 9 . 791–806 . 1997 . 8889548 . 10.1101/gr.6.9.791 . free .
Notes and References
- Hong SB, Li CM, Rhee HJ, Park JH, He X, Levy B, Yoo OJ, Schuchman EH . Molecular cloning and characterization of a human cDNA and gene encoding a novel acid ceramidase-like protein . Genomics . 62 . 2 . 232–41 . Feb 2000 . 10610717 . 10.1006/geno.1999.5953 .
- Goodchild NL, Wilkinson DA, Mager DL . A human endogenous long terminal repeat provides a polyadenylation signal to a novel, alternatively spliced transcript in normal placenta . Gene . 121 . 2 . 287–94 . Dec 1992 . 1446826 . 10.1016/0378-1119(92)90133-A .
- Web site: Entrez Gene: ASAHL N-acylsphingosine amidohydrolase (acid ceramidase)-like.
