ASAH2C explained

Neutral ceramidase C also known as N-acylsphingosine amidohydrolase 2C or non-lysosomal ceramidase C or ASAH2C is a ceramidase enzyme which in humans is encoded by the ASAH2C gene.^[1]

Further reading

• Choi MS, Anderson MA, Zhang Z, Zimonjic DB, Popescu N, Mukherjee AB . Neutral ceramidase gene: role in regulating ceramide-induced apoptosis . Gene . 315 . 113–22 . October 2003 . 14557071 . 10.1016/S0378-1119(03)00721-2 .
• El Bawab S, Roddy P, Qian T, Bielawska A, Lemasters JJ, Hannun YA . Molecular cloning and characterization of a human mitochondrial ceramidase . The Journal of Biological Chemistry . 275 . 28 . 21508–13 . July 2000 . 10781606 . 10.1074/jbc.M002522200 . free .
• Tani M, Sano T, Ito M, Igarashi Y . Mechanisms of sphingosine and sphingosine 1-phosphate generation in human platelets . Journal of Lipid Research . 46 . 11 . 2458–67 . November 2005 . 16061940 . 10.1194/jlr.M500268-JLR200 . free .
• Galadari S, Wu BX, Mao C, Roddy P, El Bawab S, Hannun YA . Identification of a novel amidase motif in neutral ceramidase . The Biochemical Journal . 393 . Pt 3 . 687–95 . February 2006 . 16229686 . 1360721 . 10.1042/BJ20050682 .
• Hwang YH, Tani M, Nakagawa T, Okino N, Ito M . Subcellular localization of human neutral ceramidase expressed in HEK293 cells . Biochemical and Biophysical Research Communications . 331 . 1 . 37–42 . May 2005 . 15845354 . 10.1016/j.bbrc.2005.03.134 .
• Osawa Y, Uchinami H, Bielawski J, Schwabe RF, Hannun YA, Brenner DA . Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha . The Journal of Biological Chemistry . 280 . 30 . 27879–87 . July 2005 . 15946935 . 10.1074/jbc.M503002200 . free .

Notes and References

1. Avramopoulos D, Wang R, Valle D, Fallin MD, Bassett SS . A novel gene derived from a segmental duplication shows perturbed expression in Alzheimer's disease . Neurogenetics . 8 . 2 . 111–20 . April 2007 . 17334805 . 10.1007/s10048-007-0081-5 . 20156514 .