ASAH2B explained

Neutral ceramidase B also known as non-lysosomal ceramidase B or N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2B or ASAH2B is a ceramidase enzyme which in humans is encoded by the ASAH2B gene.^{[1] [2]}

Clinical significance

ASAH2B shows reduced expression with increasing age and further reduction in late onset Alzheimer's disease patients.^[1]

Further reading

• Brandenberger R, Wei H, Zhang S . Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. . Nat. Biotechnol. . 22 . 6 . 707–16 . 2004 . 15146197 . 10.1038/nbt971 . 27764390 . etal.

Notes and References

1. Avramopoulos D, Wang R, Valle D, Fallin MD, Bassett SS . A novel gene derived from a segmental duplication shows perturbed expression in Alzheimer's disease . Neurogenetics . 8 . 2 . 111–20 . April 2007 . 17334805 . 10.1007/s10048-007-0081-5 . 20156514 .
2. Deloukas P, Earthrowl ME, Grafham DV . The DNA sequence and comparative analysis of human chromosome 10 . Nature . 429 . 6990 . 375–81 . May 2004 . 15164054 . 10.1038/nature02462 . 2004Natur.429..375D . etal. free .