ASAH2 explained

Neutral ceramidase is an enzyme that in humans is encoded by the ASAH2 gene.^{[1] [2]}

Further reading

• Matoba R, Okubo K, Hori N . The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression. . Gene . 146 . 2 . 199–207 . 1994 . 8076819 . 10.1016/0378-1119(94)90293-3 . etal.
• Tani M, Okino N, Mori K . Molecular cloning of the full-length cDNA encoding mouse neutral ceramidase. A novel but highly conserved gene family of neutral/alkaline ceramidases. . J. Biol. Chem. . 275 . 15 . 11229–34 . 2000 . 10753931 . 10.1074/jbc.275.15.11229 . etal. free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . etal . 2002PNAS...9916899M. free .
• Choi MS, Anderson MA, Zhang Z . Neutral ceramidase gene: role in regulating ceramide-induced apoptosis. . Gene . 315 . 113–22 . 2004 . 14557071 . 10.1016/S0378-1119(03)00721-2 . etal.
• Deloukas P, Earthrowl ME, Grafham DV . The DNA sequence and comparative analysis of human chromosome 10. . Nature . 429 . 6990 . 375–81 . 2004 . 15164054 . 10.1038/nature02462 . etal. 2004Natur.429..375D . free .
• Monick MM, Mallampalli RK, Bradford M . Cooperative prosurvival activity by ERK and Akt in human alveolar macrophages is dependent on high levels of acid ceramidase activity. . J. Immunol. . 173 . 1 . 123–35 . 2004 . 15210766 . 10.4049/jimmunol.173.1.123. etal. free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Hwang YH, Tani M, Nakagawa T . Subcellular localization of human neutral ceramidase expressed in HEK293 cells. . Biochem. Biophys. Res. Commun. . 331 . 1 . 37–42 . 2005 . 15845354 . 10.1016/j.bbrc.2005.03.134 . etal.
• Osawa Y, Uchinami H, Bielawski J . Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha. . J. Biol. Chem. . 280 . 30 . 27879–87 . 2005 . 15946935 . 10.1074/jbc.M503002200 . etal. free .
• Tani M, Sano T, Ito M, Igarashi Y . Mechanisms of sphingosine and sphingosine 1-phosphate generation in human platelets. . J. Lipid Res. . 46 . 11 . 2458–67 . 2006 . 16061940 . 10.1194/jlr.M500268-JLR200 . free .
• Galadari S, Wu BX, Mao C . Identification of a novel amidase motif in neutral ceramidase. . Biochem. J. . 393 . Pt 3 . 687–95 . 2006 . 16229686 . 10.1042/BJ20050682 . 1360721 . etal.
• Xu R, Jin J, Hu W . Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P. . FASEB J. . 20 . 11 . 1813–25 . 2006 . 16940153 . 10.1096/fj.05-5689com . free . 20973940 . etal.
• Avramopoulos D, Wang R, Valle D . A novel gene derived from a segmental duplication shows perturbed expression in Alzheimer's disease. . Neurogenetics . 8 . 2 . 111–20 . 2007. 17334805 . 10.1007/s10048-007-0081-5 . 20156514 . etal.
• Ohlsson L, Palmberg C, Duan RD . Purification and characterization of human intestinal neutral ceramidase. . Biochimie . 89 . 8 . 950–60 . 2007 . 17475390 . 10.1016/j.biochi.2007.03.009 . etal.

Notes and References

1. El Bawab S, Roddy P, Qian T, Bielawska A, Lemasters JJ, Hannun YA . Molecular cloning and characterization of a human mitochondrial ceramidase . J Biol Chem . 275 . 28 . 21508–13 . Aug 2000 . 10781606 . 10.1074/jbc.M002522200 . free .
2. Web site: Entrez Gene: ASAH2 N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2.