AS3MT explained

Arsenite methyltransferase is an enzyme that in humans is encoded by the AS3MT gene.^{[1] [2]}

Further reading

• Dheeman DS, Packianathan C, Pillai JK, Rosen BP . Pathway of human AS3MT arsenic methylation . Chemical Research in Toxicology . 27 . 11 . 1979–89 . November 2014 . 25325836 . 4237493 . 10.1021/tx500313k .
• Hernández A, Xamena N, Sekaran C, Tokunaga H, Sampayo-Reyes A, Quinteros D, Creus A, Marcos R . High arsenic metabolic efficiency in AS3MT287Thr allele carriers . Pharmacogenetics and Genomics . 18 . 4 . 349–55 . April 2008 . 18334919 . 10.1097/FPC.0b013e3282f7f46b . 25842224 .
• Fujihara J, Kunito T, Agusa T, Yasuda T, Iida R, Fujii Y, Takeshita H . Population differences in the human arsenic (+3 oxidation state) methyltransferase (AS3MT) gene polymorphism detected by using genotyping method . Toxicology and Applied Pharmacology . 225 . 3 . 251–4 . December 2007 . 17889916 . 10.1016/j.taap.2007.08.010 .
• Hernández A, Xamena N, Surrallés J, Sekaran C, Tokunaga H, Quinteros D, Creus A, Marcos R . Role of the Met(287)Thr polymorphism in the AS3MT gene on the metabolic arsenic profile . Mutation Research . 637 . 1–2 . 80–92 . January 2008 . 17850829 . 10.1016/j.mrfmmm.2007.07.004 .
• Lindberg AL, Kumar R, Goessler W, Thirumaran R, Gurzau E, Koppova K, Rudnai P, Leonardi G, Fletcher T, Vahter M . Metabolism of low-dose inorganic arsenic in a central European population: influence of sex and genetic polymorphisms . Environmental Health Perspectives . 115 . 7 . 1081–6 . July 2007 . 17637926 . 1913583 . 10.1289/ehp.10026 .
• Schläwicke Engström K, Broberg K, Concha G, Nermell B, Warholm M, Vahter M . Genetic polymorphisms influencing arsenic metabolism: evidence from Argentina . Environmental Health Perspectives . 115 . 4 . 599–605 . April 2007 . 17450230 . 1852682 . 10.1289/ehp.9734 .
• Meza M, Gandolfi AJ, Klimecki WT . Developmental and genetic modulation of arsenic biotransformation: a gene by environment interaction? . Toxicology and Applied Pharmacology . 222 . 3 . 381–7 . August 2007 . 17306849 . 2040165 . 10.1016/j.taap.2006.12.018 .
• Wood TC, Salavagionne OE, Mukherjee B, Wang L, Klumpp AF, Thomae BA, Eckloff BW, Schaid DJ, Wieben ED, Weinshilboum RM . Human arsenic methyltransferase (AS3MT) pharmacogenetics: gene resequencing and functional genomics studies . The Journal of Biological Chemistry . 281 . 11 . 7364–73 . March 2006 . 16407288 . 10.1074/jbc.M512227200 . free .
• Meza MM, Yu L, Rodriguez YY, Guild M, Thompson D, Gandolfi AJ, Klimecki WT . Developmentally restricted genetic determinants of human arsenic metabolism: association between urinary methylated arsenic and CYT19 polymorphisms in children . Environmental Health Perspectives . 113 . 6 . 775–81 . June 2005 . 15929903 . 1257606 . 10.1289/ehp.7780 .
• Li J, Waters SB, Drobna Z, Devesa V, Styblo M, Thomas DJ . Arsenic (+3 oxidation state) methyltransferase and the inorganic arsenic methylation phenotype . Toxicology and Applied Pharmacology . 204 . 2 . 164–9 . April 2005 . 15808521 . 10.1016/j.taap.2004.12.002 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . October 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . January 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .

Notes and References

1. Lin S, Shi Q, Nix FB, Styblo M, Beck MA, Herbin-Davis KM, Hall LL, Simeonsson JB, Thomas DJ . A novel S-adenosyl-L-methionine:arsenic(III) methyltransferase from rat liver cytosol . The Journal of Biological Chemistry . 277 . 13 . 10795–803 . March 2002 . 11790780 . 10.1074/jbc.M110246200 . free .
2. Web site: Entrez Gene: AS3MT arsenic (+3 oxidation state) methyltransferase.