AS-8112 explained

AS-8112 is a synthetic compound that acts as a selective antagonist at the dopamine receptor subtypes D₂ and D₃, and the serotonin receptor 5-HT₃.^[1] It has potent antiemetic effects in animal studies and has been investigated for potential medical use.^{[2] [3]}

Notes and References

1. Yoshikawa T, Yoshida N, Oka M . The broad-spectrum anti-emetic activity of AS-8112, a novel dopamine D2, D3 and 5-HT3 receptors antagonist . . 133 . 2 . 253–60 . May 2001 . 11350861 . 1572785 . 10.1038/sj.bjp.0704078 .
2. Yoshikawa T, Yoshida N, Oka M . Central antiemetic effects of AS-8112, a dopamine D2, D3, and 5-HT(3) receptor antagonist, in ferrets . European Journal of Pharmacology . 431 . 3 . 361–4 . November 2001 . 11730730 . 10.1016/S0014-2999(01)01459-5.
3. Hirokawa Y, Fujiwara I, Suzuki K, Harada H, Yoshikawa T, Yoshida N, Kato S . Synthesis and structure-affinity relationships of novel N-(1-ethyl-4-methylhexahydro-1,4-diazepin-6-yl)pyridine-3-carboxamides with potent serotonin 5-HT3 and dopamine D2 receptor antagonistic activity . Journal of Medicinal Chemistry . 46 . 5 . 702–15 . February 2003 . 12593651 . 10.1021/jm020270n .