AS-19 (drug) explained

AS-19 is a substance which acts as a potent agonist at the 5-HT₇ receptor, with an IC₅₀ of 0.83 nM. It reverses the amnesia induced by drugs such as scopolamine and dizocilpine and improves long-term memory acquisition, but inhibits short-term memory formation.^{[1] [2]}

See also

• E-55888
• LP-12
• LP-44
• LP-211

Notes and References

1. Meneses A, Perez-Garcia G, Liy-Salmeron G, Flores-Galvez D, Castillo C, Castillo E . The effects of the 5-HT(6) receptor agonist EMD and the 5-HT(7) receptor agonist AS19 on memory formation . Behavioural Brain Research . 195 . 1 . 112–9 . December 2008 . 18191236 . 10.1016/j.bbr.2007.11.023 . 144901859 .
2. Perez-García G, Meneses A . Ex vivo study of 5-HT(1A) and 5-HT(7) receptor agonists and antagonists on cAMP accumulation during memory formation and amnesia . Behavioural Brain Research . 195 . 1 . 139–46 . December 2008 . 18723050 . 10.1016/j.bbr.2008.07.033 . 140204255 .