ARNT2 explained

Aryl hydrocarbon receptor nuclear translocator 2 is a protein that in humans is encoded by the ARNT2 gene.^{[1] [2]}

This gene encodes a member of the basic-helix-loop-helix-Per-Arnt-Sim (bHLH-PAS) superfamily of transcription factors. The encoded protein acts as a partner for several sensor proteins of the bHLH-PAS family, forming heterodimers with the sensor proteins that bind regulatory DNA sequences in genes responsive to developmental and environmental stimuli. Under hypoxic conditions, the encoded protein complexes with hypoxia-inducible factor 1alpha in the nucleus and this complex binds to hypoxia-responsive elements in enhancers and promoters of oxygen-responsive genes. A highly similar protein in mouse forms functional complexes with both aryl hydrocarbon receptors and Single-minded proteins, suggesting addition roles for the encoded protein in the metabolism of xenobiotic compounds and the regulation of neurogenesis, respectively.^[2]

Further reading

• Nagase T, Ishikawa K, Nakajima D . Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. . DNA Res. . 4 . 2 . 141–50 . 1997 . 9205841 . 10.1093/dnares/4.2.141 . etal. free .
• Moffett P, Pelletier J . Different transcriptional properties of mSim-1 and mSim-2. . FEBS Lett. . 466 . 1 . 80–6 . 2000 . 10648817 . 10.1016/S0014-5793(99)01750-0 . 30972686 .
• Hartley JL, Temple GF, Brasch MA . DNA cloning using in vitro site-specific recombination. . Genome Res. . 10 . 11 . 1788–95 . 2001 . 11076863 . 10.1101/gr.143000 . 310948 .
• Wiemann S, Weil B, Wellenreuther R . Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. . Genome Res. . 11 . 3 . 422–35 . 2001 . 11230166 . 10.1101/gr.GR1547R . 311072 . etal.
• Barrow LL, Wines ME, Romitti PA . Aryl hydrocarbon receptor nuclear translocator 2 (ARNT2): structure, gene mapping, polymorphisms, and candidate evaluation for human orofacial clefts. . Teratology . 66 . 2 . 85–90 . 2003 . 12210012 . 10.1002/tera.10062 . etal.
• Stolze I, Berchner-Pfannschmidt U, Freitag P . Hypoxia-inducible erythropoietin gene expression in human neuroblastoma cells. . Blood . 100 . 7 . 2623–8 . 2002 . 12239177 . 10.1182/blood-2001-12-0169 . etal. free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Ooe N, Saito K, Mikami N . Identification of a novel basic helix-loop-helix-PAS factor, NXF, reveals a Sim2 competitive, positive regulatory role in dendritic-cytoskeleton modulator drebrin gene expression. . Mol. Cell. Biol. . 24 . 2 . 608–16 . 2004 . 14701734 . 10.1128/MCB.24.2.608-616.2004 . 343817 . etal.
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Wiemann S, Arlt D, Huber W . From ORFeome to biology: a functional genomics pipeline. . Genome Res. . 14 . 10B . 2136–44 . 2004 . 15489336 . 10.1101/gr.2576704 . 528930 . etal.
• Mehrle A, Rosenfelder H, Schupp I . The LIFEdb database in 2006. . Nucleic Acids Res. . 34 . Database issue . D415–8 . 2006 . 16381901 . 10.1093/nar/gkj139 . 1347501 . etal.
• Friedman ER, Fan CM . Separate necdin domains bind ARNT2 and HIF1alpha and repress transcription. . Biochem. Biophys. Res. Commun. . 363 . 1 . 113–8 . 2007 . 17826745 . 10.1016/j.bbrc.2007.08.108 . 2083645 .

Notes and References

1. Wines ME, Lee L, Katari MS, Zhang L, DeRossi C, Shi Y, Perkins S, Feldman M, McCombie WR, Holdener BC . Identification of mesoderm development (mesd) candidate genes by comparative mapping and genome sequence analysis . Genomics . 72 . 1 . 88–98 . Mar 2001 . 11247670 . 10.1006/geno.2000.6466 .
2. Web site: Entrez Gene: ARNT2 aryl-hydrocarbon receptor nuclear translocator 2.