ARMCX6 explained

Armadillo repeat containing X-linked 6 is a protein that in humans is encoded by the ARMCX6 gene located on the X-chromosome.^[1]

It is one of six armadillo repeats containing X-linked proteins (ARMCX1, ARMCX2, ARMCX3, ARMCX4, ARMCX5, and ARMCX6 (this protein)).

The function of this protein is unknown at this time.

Protein sequence

     1 MGRAREVGWM AAGLMIGAGA CYCVYKLTIG RDDSEKLEEE 
    41 GEEEWDDDQE LDEEEPDIWF DFETMARPWT EDGDWTEPGA 
    81 PGGTEDRPSG GGKANRAHPI KQRPFPYEHK NTWSAQNCKN 
   121 GSCVLDLSKC LFIQGKLLFA EPKDAGFPFS QDINSHLASL 
   161 SMARNTSPTP DPTVREALCA PDNLNASIES QGQIKMYINE 
   201 VCRETVSRCC NSFLQQAGLN LLISMTVINN MLAKSASDLK 
   241 FPLISEGSGC AKVQVLKPLM GLSEKPVLAG ELVGAQMLFS 
   301 FMSLFIRNGN REILLETPAP

Homology

ARMCX6 is conserved in many eukaryotic organisms.

Orthologs

taxonomic name	common name	NCBI entry	Percentage of sequence similarity	Length (AAs)	comments
Homo sapiens	Human	https://www.ncbi.nlm.nih.gov/protein/33873720	100%	300	armadillo repeat containing X-linked 6
Macaca mulatta	Rhesus monkey	https://www.ncbi.nlm.nih.gov/protein/109131576	97.0%	300	PREDICTED: similar to amrmadillo repeat containing, X-linked 6 (H. sapiens)-like isoform 1
Equus caballus	Horse	https://www.ncbi.nlm.nih.gov/protein/149755221	90.0%	300	PREDICTED: similar to armadillo repeat containing, X-linked 6
Danio rerio	zebrafish	https://www.ncbi.nlm.nih.gov/protein/47086327	84.0%	301	Similar to RIKEN cDNA 0610039K22
Mus musculus	House Mouse	https://www.ncbi.nlm.nih.gov/protein/16359216	97.7%	393	armadillo repeat containing, X-linked 6 (H. sapiens)-like
Bos taurus	cow	https://www.ncbi.nlm.nih.gov/protein/118151322	83.0%	301	armadillo repeat containing, X-linked 6
Mus musculus	Mouse	https://www.ncbi.nlm.nih.gov/protein/56090483	82.0%	301	armadillo repeat containing, X-linked 6
Takifugu rubripes	Tetradontoidea	https://www.ncbi.nlm.nih.gov/protein/83817017	66.0%	818	aryl hydrocarbon receptor 2C
Caenorhabditis elegans	C. elegans	https://www.ncbi.nlm.nih.gov/protein/17564466	50.0%	332	Serpentine Receptor, class H family member (srh-216)
Saccharomyces cerevisiae	Yeast	https://www.ncbi.nlm.nih.gov/protein/6321297	70.0%	910	Hul5p
Gallus gallus	Chicken	https://www.ncbi.nlm.nih.gov/protein/118082062	52.0%	317	PREDICTED: hypothetical protein

Secondary Structure

The secondary structure of ARMCX6 is predicted to be similar to cyanase. A comparison of the two sequences is shown below.^{[2] [3]}

                          10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
ARMCX6      231 MLAKSASDLKFPLISEGSGCAKVQVLKPLMGLSEKPVLAGELVGAQM 277
1DW9_A       19 LLSKAKKDLSFAEIADGTGLAEAFVTAALLGQQALPADAARLVGAKL 65
                 + +   ++ +  +  + + +   +   + +    +  +  ++++

Expression

Microarray data show that ARMCX6 is highly expressed during earliest stages of spermatogenesis in mice.^{[4] [5] [6]}

Further reading

• Ross MT, Grafham DV, Coffey AJ . The DNA sequence of the human X chromosome . Nature . 434 . 7031 . 325–37 . 2005 . 15772651 . 10.1038/nature03440 . 2665286. 2005Natur.434..325R . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2002 . 12477932 . 10.1073/pnas.242603899 . 139241. 2002PNAS...9916899M . etal. free .
• Olsen JV, Blagoev B, Gnad F . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928. etal.
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .

Notes and References

1. Web site: Entrez Gene: armadillo repeat containing.
2. http://workbench.sdsc.edu/ SDSC Biology Workbench 2.0
3. Web site: CBlast service is retiring.
4. https://www.ncbi.nlm.nih.gov/UniGene/ESTProfileViewer.cgi?uglist=Hs.22157 EST Profile Viewer- Human
5. https://www.ncbi.nlm.nih.gov/UniGene/ESTProfileViewer.cgi?uglist=Mm.331805 EST Profile Viewer- Mouse
6. Su AI, Wiltshire T, Batalov S, Lapp H . A gene atlas of the mouse and human protein-encoding transcriptomes . Proceedings of the National Academy of Sciences of the United States of America . 101 . 16 . 6062–7 . April 2004 . 10.1073/pnas.0400782101 . 15075390 . 395923. 2004PNAS..101.6062S . etal. free .