ARL6IP5 explained

PRA1 family protein 3 is a protein that in humans is encoded by the ARL6IP5 gene.^{[1] [2] [3]}

Function

Expression of this gene is affected by vitamin A. The encoded protein of this gene may be associated with the cytoskeleton. A similar protein in rats may play a role in the regulation of cell differentiation. The rat protein binds and inhibits the cell membrane glutamate transporter EAAC1. The expression of the rat gene is upregulated by retinoic acid, which results in a specific reduction in EAAC1-mediated glutamate transport. The disruption of the mouse gene results in increased neuronal glutathione content, neuroprotection against oxidative stress and a better performance in motor/spatial learning and memory tests than wild-type mice.

Interactions

ARL6IP5 has been shown to interact with SLC1A1.

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 . etal.
• Ingley E, Williams JH, Walker CE . A novel ADP-ribosylation like factor (ARL-6), interacts with the protein-conducting channel SEC61beta subunit. . FEBS Lett. . 459 . 1 . 69–74 . 1999 . 10508919 . 10.1016/S0014-5793(99)01188-6 . 30948975 . etal.
• Butchbach ME, Lai L, Lin CL . Molecular cloning, gene structure, expression profile and functional characterization of the mouse glutamate transporter (EAAT3) interacting protein GTRAP3-18. . Gene . 292 . 1–2 . 81–90 . 2002 . 12119102 . 10.1016/S0378-1119(02)00669-8 .
• Ikemoto MJ, Inoue K, Akiduki S . Identification of addicsin/GTRAP3-18 as a chronic morphine-augmented gene in amygdala. . NeuroReport . 13 . 16 . 2079–84 . 2003 . 12438930 . 10.1097/00001756-200211150-00018 . 43751076 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Butchbach ME, Guo H, Lin CL . Methyl-beta-cyclodextrin but not retinoic acid reduces EAAT3-mediated glutamate uptake and increases GTRAP3-18 expression. . J. Neurochem. . 84 . 4 . 891–4 . 2003 . 12562531 . 10.1046/j.1471-4159.2003.01588.x . 23283506 .
• Gevaert K, Goethals M, Martens L . Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. . Nat. Biotechnol. . 21 . 5 . 566–9 . 2004 . 12665801 . 10.1038/nbt810 . 23783563 . etal.
• Matsuda A, Suzuki Y, Honda G . Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. . Oncogene . 22 . 21 . 3307–18 . 2003 . 12761501 . 10.1038/sj.onc.1206406 . 38880905 . etal.
• Mao WG, Li AP, Ye J . [Effect of differentiation inducer and heat stress on the expression of JWA protein and Hsp70 of K562 cells] . Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi . 21 . 4 . 253–6 . 2004 . 14761432 . etal.
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Schweneker M, Bachmann AS, Moelling K . JM4 is a four-transmembrane protein binding to the CCR5 receptor. . FEBS Lett. . 579 . 7 . 1751–8 . 2005 . 15757671 . 10.1016/j.febslet.2005.02.037 . 1173694 . free .
• Zhu T, Chen R, Li AP . Regulation of a novel cell differentiation-associated gene, JWA during oxidative damage in K562 and MCF-7 cells. . J. Biomed. Sci. . 12 . 1 . 219–27 . 2005 . 15864752 . 10.1007/s11373-004-8186-4 . etal.
• Rual JF, Venkatesan K, Hao T . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 . etal.
• Otsuki T, Ota T, Nishikawa T . Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. . DNA Res. . 12 . 2 . 117–26 . 2007 . 16303743 . 10.1093/dnares/12.2.117 . etal. free .
• Huang S, Shen Q, Mao WG . JWA, a novel signaling molecule, involved in the induction of differentiation of human myeloid leukemia cells. . Biochem. Biophys. Res. Commun. . 341 . 2 . 440–50 . 2006 . 16430862 . 10.1016/j.bbrc.2005.12.197 . etal.
• Huang S, Shen Q, Mao WG . JWA, a novel signaling molecule, involved in all-trans retinoic acid induced differentiation of HL-60 cells. . J. Biomed. Sci. . 13 . 3 . 357–71 . 2006 . 16468075 . 10.1007/s11373-005-9068-0 . etal. free .
• Fo CS, Coleman CS, Wallick CJ . Genomic organization, expression profile, and characterization of the new protein PRA1 domain family, member 2 (PRAF2). . Gene . 371 . 1 . 154–65 . 2006 . 16481131 . 10.1016/j.gene.2005.12.009 . etal.
• Aoyama K, Wang F, Matsumura N . Increased neuronal glutathione and neuroprotection in GTRAP3-18-deficient mice. . Neurobiol Dis . 45 . 3 . 973–82 . 2012 . 22210510 . 10.1016/j.nbd.2011.12.016 . 22266026 . etal.

Notes and References

1. Lin CI, Orlov I, Ruggiero AM, Dykes-Hoberg M, Lee A, Jackson M, Rothstein JD . Modulation of the neuronal glutamate transporter EAAC1 by the interacting protein GTRAP3-18 . Nature . 410 . 6824 . 84–8 . Mar 2001 . 11242046 . 10.1038/35065084 . 4622513 .
2. Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z . Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells . Genome Res . 10 . 10 . 1546–60 . Nov 2000 . 11042152 . 310934 . 10.1101/gr.140200 .
3. Web site: Entrez Gene: ARL6IP5 ADP-ribosylation-like factor 6 interacting protein 5.