ARL4D explained

ADP-ribosylation factor-like protein 4D is a protein that in humans is encoded by the ARL4D gene.^{[1] [2]}

Function

ADP-ribosylation factor 4D is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL4D is closely similar to ARL4A and ARL4C and each has a nuclear localization signal and an unusually high guanine nucleotide exchange rate. This protein may play a role in membrane-associated intracellular trafficking. Mutations in this gene have been associated with Bardet–Biedl syndrome (BBS).^[2]

Further reading

• Miki Y, Swensen J, Shattuck-Eidens D, Futreal PA, Harshman K, Tavtigian S, Liu Q, Cochran C, Bennett LM, Ding W . A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1 . Science . 266 . 5182 . 66–71 . Oct 1994 . 7545954 . 10.1126/science.7545954 . 1994Sci...266...66M . free .
• Harshman K, Bell R, Rosenthal J, Katcher H, Miki Y, Swenson J, Gholami Z, Frye C, Ding W, Dayananth P . Comparison of the positional cloning methods used to isolate the BRCA1 gene . Human Molecular Genetics . 4 . 8 . 1259–66 . Aug 1995 . 7581362 . 10.1093/hmg/4.8.1259 .
• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery . Genome Research . 6 . 9 . 791–806 . Sep 1996 . 8889548 . 10.1101/gr.6.9.791 . free .
• Jacobs S, Schilf C, Fliegert F, Koling S, Weber Y, Schürmann A, Joost HG . ADP-ribosylation factor (ARF)-like 4, 6, and 7 represent a subgroup of the ARF family characterization by rapid nucleotide exchange and a nuclear localization signal . FEBS Letters . 456 . 3 . 384–8 . Aug 1999 . 10462049 . 10.1016/S0014-5793(99)00759-0 . 84422541 . free .
• Ingley E, Williams JH, Walker CE, Tsai S, Colley S, Sayer MS, Tilbrook PA, Sarna M, Beaumont JG, Klinken SP . A novel ADP-ribosylation like factor (ARL-6), interacts with the protein-conducting channel SEC61beta subunit . FEBS Letters . 459 . 1 . 69–74 . Oct 1999 . 10508919 . 10.1016/S0014-5793(99)01188-6 . 30948975 . free .
• Nonaka Y, Tsuda N, Shichijo S, Ito M, Maeda Y, Harada M, Kamura T, Shigemori M, Itoh K . Recognition of ADP-ribosylation factor 4-like by HLA-A2-restricted and tumor-reactive cytotoxic T lymphocytes from patients with brain tumors . Tissue Antigens . 60 . 4 . 319–27 . Oct 2002 . 12472661 . 10.1034/j.1399-0039.2002.600406.x .
• Chiang AP, Nishimura D, Searby C, Elbedour K, Carmi R, Ferguson AL, Secrist J, Braun T, Casavant T, Stone EM, Sheffield VC . Comparative genomic analysis identifies an ADP-ribosylation factor-like gene as the cause of Bardet-Biedl syndrome (BBS3) . American Journal of Human Genetics . 75 . 3 . 475–84 . Sep 2004 . 15258860 . 1182025 . 10.1086/423903 .
• Fan Y, Esmail MA, Ansley SJ, Blacque OE, Boroevich K, Ross AJ, Moore SJ, Badano JL, May-Simera H, Compton DS, Green JS, Lewis RA, van Haelst MM, Parfrey PS, Baillie DL, Beales PL, Katsanis N, Davidson WS, Leroux MR . Mutations in a member of the Ras superfamily of small GTP-binding proteins causes Bardet-Biedl syndrome . Nature Genetics . 36 . 9 . 989–93 . Sep 2004 . 15314642 . 10.1038/ng1414 . free .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . Oct 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Hofmann I, Thompson A, Sanderson CM, Munro S . The Arl4 family of small G proteins can recruit the cytohesin Arf6 exchange factors to the plasma membrane . Current Biology . 17 . 8 . 711–6 . Apr 2007 . 17398095 . 10.1016/j.cub.2007.03.007 . 1341183 . free . 2007CBio...17..711H .

Notes and References

1. Smith SA, Holik PR, Stevens J, Melis R, White R, Albertsen H . Isolation and mapping of a gene encoding a novel human ADP-ribosylation factor on chromosome 17q12-q21 . Genomics . 28 . 1 . 113–5 . Jul 1995 . 7590735 . 10.1006/geno.1995.1115 .
2. Web site: Entrez Gene: ARL4D ADP-ribosylation factor-like 4D.