ARL3 explained

ADP-ribosylation factor-like protein 3 is a protein that in humans is encoded by the ARL3 gene.^{[1] [2] [3]}

Function

ADP-ribosylation factor-like 3 is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL3 binds guanine nucleotides but lacks ADP-ribosylation factor activity.

Interactions

ARL3 has been shown to interact with Protein unc-119 homolog.^{[4] [5]}

Further reading

• Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O . Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence . Nature . 377 . 6547 Suppl . 3–174 . 1995 . 7566098 . .
• Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA . A "double adaptor" method for improved shotgun library construction . Anal. Biochem. . 236 . 1 . 107–13 . 1996 . 8619474 . 10.1006/abio.1996.0138 .
• Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA . Large-scale concatenation cDNA sequencing . Genome Res. . 7 . 4 . 353–8 . 1997 . 9110174 . 139146 . 10.1101/gr.7.4.353 .
• Linari M, Hanzal-Bayer M, Becker J . The delta subunit of rod specific cyclic GMP phosphodiesterase, PDE delta, interacts with the Arf-like protein Arl3 in a GTP specific manner . FEBS Lett. . 458 . 1 . 55–9 . 1999 . 10518933 . 10.1016/S0014-5793(99)01117-5 . 23460401 .
• Hillig RC, Hanzal-Bayer M, Linari M, Becker J, Wittinghofer A, Renault L . Structural and biochemical properties show ARL3-GDP as a distinct GTP binding protein . Structure . 8 . 12 . 1239–45 . 2000 . 11188688 . 10.1016/S0969-2126(00)00531-1 . free .
• Bartolini F, Bhamidipati A, Thomas S, Schwahn U, Lewis SA, Cowan NJ . Functional overlap between retinitis pigmentosa 2 protein and the tubulin-specific chaperone cofactor C . J. Biol. Chem. . 277 . 17 . 14629–34 . 2002 . 11847227 . 10.1074/jbc.M200128200 . free .
• Hanzal-Bayer M, Renault L, Roversi P, Wittinghofer A, Hillig RC . The complex of Arl2-GTP and PDE delta: from structure to function . EMBO J. . 21 . 9 . 2095–106 . 2002 . 11980706 . 125981 . 10.1093/emboj/21.9.2095 .
• Wistow G, Bernstein SL, Wyatt MK, Ray S, Behal A, Touchman JW, Bouffard G, Smith D, Peterson K . Expressed sequence tag analysis of human retina for the NEIBank Project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts . Mol. Vis. . 8 . 196–204 . 2002 . 12107411 .
• Grayson C, Bartolini F, Chapple JP, Willison KR, Bhamidipati A, Lewis SA, Luthert PJ, Hardcastle AJ, Cowan NJ, Cheetham ME . Localization in the human retina of the X-linked retinitis pigmentosa protein RP2, its homologue cofactor C and the RP2 interacting protein Arl3 . Hum. Mol. Genet. . 11 . 24 . 3065–74 . 2002 . 12417528 . 10.1093/hmg/11.24.3065 . free .
• Kühnel K, Veltel S, Schlichting I, Wittinghofer A . Crystal structure of the human retinitis pigmentosa 2 protein and its interaction with Arl3 . Structure . 14 . 2 . 367–78 . 2006 . 16472755 . 10.1016/j.str.2005.11.008 . free . 11858/00-001M-0000-0015-8B49-9 . free .
• Zhou C, Cunningham L, Marcus AI, Li Y, Kahn RA . Arl2 and Arl3 regulate different microtubule-dependent processes . Mol. Biol. Cell . 17 . 5 . 2476–87 . 2006 . 16525022 . 1446103 . 10.1091/mbc.E05-10-0929 .

Notes and References

1. Cavenagh MM, Breiner M, Schurmann A, Rosenwald AG, Terui T, Zhang C, Randazzo PA, Adams M, Joost HG, Kahn RA . ADP-ribosylation factor (ARF)-like 3, a new member of the ARF family of GTP-binding proteins cloned from human and rat tissues . J. Biol. Chem. . 269 . 29 . 18937–42 . August 1994 . 10.1016/S0021-9258(17)32257-3 . 8034651 . free .
2. Kim HS . Assignment of the human ADP-ribosylation factor-like 3 (ARL3) gene to chromosome 10 band q23.3 by radiation hybrid mapping . Cytogenet. Cell Genet. . 83 . 3–4 . 246 . 1998 . 10072593 . 10.1159/000015194 . 35440803 .
3. Web site: Entrez Gene: ARL3 ADP-ribosylation factor-like 3.
4. Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE . A human protein-protein interaction network: a resource for annotating the proteome . Cell . 122 . 6 . 957–68 . September 2005 . 16169070 . 10.1016/j.cell.2005.08.029 . 11858/00-001M-0000-0010-8592-0 . 8235923 . free .
5. Van Valkenburgh H, Shern JF, Sharer JD, Zhu X, Kahn RA . ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins . J. Biol. Chem. . 276 . 25 . 22826–37 . June 2001 . 11303027 . 10.1074/jbc.M102359200 . free .