ARIH2 explained
Protein ariadne-2 homolog is a protein that in humans is encoded by the ARIH2 gene.[1] [2]
Function
ARIH2 influences development of Mll-Ell-induced acute myeloid leukemia and regulate the proliferation,[3] DNA damage and chemosensitivity of gastric cancer cells by reducing the stability of p21 via ubiquitination,[4] ARIH2 Ubiquitinates NLRP3 and Negatively Regulates NLRP3 Inflammasome Activation in Macrophages.[5]
Further reading
- Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–174 . January 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–156 . October 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
- Aguilera M, Oliveros M, Martínez-Padrón M, Barbas JA, Ferrús A . Ariadne-1: a vital Drosophila gene is required in development and defines a new conserved family of ring-finger proteins . Genetics . 155 . 3 . 1231–1244 . July 2000 . 10880484 . 1461160 . 10.1093/genetics/155.3.1231 .
- Hu RM, Han ZG, Song HD, Peng YD, Huang QH, Ren SX, Gu YJ, Huang CH, Li YB, Jiang CL, Fu G, Zhang QH, Gu BW, Dai M, Mao YF, Gao GF, Rong R, Ye M, Zhou J, Xu SH, Gu J, Shi JX, Jin WR, Zhang CK, Wu TM, Huang GY, Chen Z, Chen MD, Chen JL . 6 . Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning . Proceedings of the National Academy of Sciences of the United States of America . 97 . 17 . 9543–9548 . August 2000 . 10931946 . 16901 . 10.1073/pnas.160270997 . free . 2000PNAS...97.9543H .
- Wong ES, Fong CW, Lim J, Yusoff P, Low BC, Langdon WY, Guy GR . Sprouty2 attenuates epidermal growth factor receptor ubiquitylation and endocytosis, and consequently enhances Ras/ERK signalling . The EMBO Journal . 21 . 18 . 4796–4808 . September 2002 . 12234920 . 126289 . 10.1093/emboj/cdf493 .
- Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW . 6 . Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation . Nature Biotechnology . 22 . 6 . 707–716 . June 2004 . 15146197 . 10.1038/nbt971 . 27764390 .
- Marteijn JA, van Emst L, Erpelinck-Verschueren CA, Nikoloski G, Menke A, de Witte T, Löwenberg B, Jansen JH, van der Reijden BA . 6 . The E3 ubiquitin-protein ligase Triad1 inhibits clonogenic growth of primary myeloid progenitor cells . Blood . 106 . 13 . 4114–4123 . December 2005 . 16118314 . 10.1182/blood-2005-04-1450 . free .
- Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE . 6 . A human protein-protein interaction network: a resource for annotating the proteome . Cell . 122 . 6 . 957–968 . September 2005 . 16169070 . 10.1016/j.cell.2005.08.029 . free . 8235923 . 11858/00-001M-0000-0010-8592-0 .
- Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . 6 . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–1178 . October 2005 . 16189514 . 10.1038/nature04209 . 4427026 . 2005Natur.437.1173R .
- Marteijn JA, van der Meer LT, van Emst L, van Reijmersdal S, Wissink W, de Witte T, Jansen JH, Van der Reijden BA . 6 . Gfi1 ubiquitination and proteasomal degradation is inhibited by the ubiquitin ligase Triad1 . Blood . 110 . 9 . 3128–3135 . November 2007 . 17646546 . 10.1182/blood-2006-11-058602 . free .
Notes and References
- van der Reijden BA, Erpelinck-Verschueren CA, Löwenberg B, Jansen JH . TRIADs: a new class of proteins with a novel cysteine-rich signature . Protein Science . 8 . 7 . 1557–1561 . July 1999 . 10422847 . 2144383 . 10.1110/ps.8.7.1557 .
- Web site: Entrez Gene: ARIH2 ariadne homolog 2 (Drosophila).
- Wang H, Bei L, Shah CA, Huang W, Platanias LC, Eklund EA . The E3 ubiquitin ligase Triad1 influences development of Mll-Ell-induced acute myeloid leukemia . Oncogene . 37 . 19 . 2532–2544 . May 2018 . 29459712 . 5945580 . 10.1038/s41388-018-0131-5 .
- Geng S, Peng W, Wang X, Hu X, Liang H, Hou J, Wang F, Zhao G, Lü M, Cui H . 6 . ARIH2 regulates the proliferation, DNA damage and chemosensitivity of gastric cancer cells by reducing the stability of p21 via ubiquitination . Cell Death & Disease . 13 . 6 . 564 . June 2022 . 35732617 . 9218151 . 10.1038/s41419-022-04965-9 .
- Kawashima A, Karasawa T, Tago K, Kimura H, Kamata R, Usui-Kawanishi F, Watanabe S, Ohta S, Funakoshi-Tago M, Yanagisawa K, Kasahara T, Suzuki K, Takahashi M . 6 . ARIH2 Ubiquitinates NLRP3 and Negatively Regulates NLRP3 Inflammasome Activation in Macrophages . Journal of Immunology . 199 . 10 . 3614–3622 . November 2017 . 29021376 . 10.4049/jimmunol.1700184 . free .