ARID4B explained
AT-rich interactive domain-containing protein 4B is a protein that in humans is encoded by the ARID4B gene.[1] [2]
Function
This gene encodes a protein with sequence similarity to retinoblastoma-binding protein-1. The encoded protein is a subunit of the histone deacetylase-dependent SIN3A transcriptional corepressor complex, which functions in diverse cellular processes including proliferation, differentiation, apoptosis, oncogenesis, and cell fate determination. The gene product is recognized by IgG antibody isolated from a breast cancer patient and appears to be a molecular marker associated with a broad range of human malignancies. Alternate transcriptional splice variants encoding different isoforms have been characterized.[2]
Further reading
- Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI . Directed proteomic analysis of the human nucleolus. . Curr. Biol. . 12 . 1 . 1–11 . 2002 . 11790298 . 10.1016/S0960-9822(01)00650-9 . 14132033 . free .
- Bommel H, Xie G, Rossoll W, Wiese S, Jablonka S, Boehm T, Sendtner M . Missense mutation in the tubulin-specific chaperone E (Tbce) gene in the mouse mutant progressive motor neuronopathy, a model of human motoneuron disease. . J. Cell Biol. . 159 . 4 . 563–9 . 2003 . 12446740 . 2173089 . 10.1083/jcb.200208001 .
- Fleischer TC, Yun UJ, Ayer DE . Identification and characterization of three new components of the mSin3A corepressor complex. . Mol. Cell. Biol. . 23 . 10 . 3456–67 . 2003 . 12724404 . 164750 . 10.1128/MCB.23.10.3456-3467.2003 .
- Cui D, Jin G, Gao T, Sun T, Tian F, Estrada GG, Gao H, Sarai A . Characterization of BRCAA1 and its novel antigen epitope identification. . Cancer Epidemiol. Biomarkers Prev. . 13 . 7 . 1136–45 . 2004 . 10.1158/1055-9965.1136.13.7 . 15247124 . 28408982 . free .
- Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP . Large-scale characterization of HeLa cell nuclear phosphoproteins. . Proc. Natl. Acad. Sci. U.S.A. . 101 . 33 . 12130–5 . 2004 . 15302935 . 514446 . 10.1073/pnas.0404720101 . 2004PNAS..10112130B . free .
- Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .
Notes and References
- Cao J, Gao T, Stanbridge EJ, Irie R . RBP1L1, a retinoblastoma-binding protein-related gene encoding an antigenic epitope abundantly expressed in human carcinomas and normal testis . J Natl Cancer Inst . 93 . 15 . 1159–65 . Aug 2001 . 11481388 . 10.1093/jnci/93.15.1159 . free .
- Web site: Entrez Gene: ARID4B AT rich interactive domain 4B (RBP1-like).
