ARID4A explained

AT rich interactive domain 4A (RBP1-like), also known as ARID4A, is a protein which in humans is encoded by the ARID4A gene.^{[1] [2] [3]}

Function

The protein encoded by this gene is a ubiquitously expressed nuclear protein. It binds directly, with several other proteins, to retinoblastoma protein (pRB) which regulates cell proliferation. pRB represses transcription by recruiting the encoded protein. This protein, in turn, serves as a bridging molecule to recruit HDACs and, in addition, provides a second HDAC-independent repression function. The encoded protein possesses transcriptional repression activity. Multiple alternatively spliced transcripts have been observed for this gene, although not all transcript variants have been fully described.^[1]

Interactions

ARID4A has been shown to interact with Retinoblastoma protein.^[4]

Further reading

• Defeo-Jones D, Huang PS, Jones RE, Haskell KM, Vuocolo GA, Hanobik MG, Huber HE, Oliff A . Cloning of cDNAs for cellular proteins that bind to the retinoblastoma gene product . Nature . 352 . 6332 . 251–4 . Jul 1991 . 1857421 . 10.1038/352251a0 . 1991Natur.352..251D . 4357523 .
• Fattaey AR, Helin K, Dembski MS, Dyson N, Harlow E, Vuocolo GA, Hanobik MG, Haskell KM, Oliff A, Defeo-Jones D . Characterization of the retinoblastoma binding proteins RBP1 and RBP2 . Oncogene . 8 . 11 . 3149–56 . Nov 1993 . 8414517 .
• Otterson GA, Kratzke RA, Lin AY, Johnston PG, Kaye FJ . Alternative splicing of the RBP1 gene clusters in an internal exon that encodes potential phosphorylation sites . Oncogene . 8 . 4 . 949–57 . Apr 1993 . 8455946 .
• Margottin F, Bour SP, Durand H, Selig L, Benichou S, Richard V, Thomas D, Strebel K, Benarous R . A novel human WD protein, h-beta TrCp, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-box motif . Molecular Cell . 1 . 4 . 565–74 . Mar 1998 . 9660940 . 10.1016/S1097-2765(00)80056-8 . free .
• Lai A, Marcellus RC, Corbeil HB, Branton PE . RBP1 induces growth arrest by repression of E2F-dependent transcription . Oncogene . 18 . 12 . 2091–100 . Mar 1999 . 10321733 . 10.1038/sj.onc.1202520 . free .
• Cao J, Gao T, Giuliano AE, Irie RF . Recognition of an epitope of a breast cancer antigen by human antibody . Breast Cancer Research and Treatment . 53 . 3 . 279–90 . Feb 1999 . 10369074 . 10.1023/A:1006115922401 . 34896754 .
• Lai A, Lee JM, Yang WM, DeCaprio JA, Kaelin WG, Seto E, Branton PE . RBP1 recruits both histone deacetylase-dependent and -independent repression activities to retinoblastoma family proteins . Molecular and Cellular Biology . 19 . 10 . 6632–41 . Oct 1999 . 10490602 . 84642 . 10.1128/mcb.19.10.6632.
• Lai A, Kennedy BK, Barbie DA, Bertos NR, Yang XJ, Theberge MC, Tsai SC, Seto E, Zhang Y, Kuzmichev A, Lane WS, Reinberg D, Harlow E, Branton PE . RBP1 recruits the mSIN3-histone deacetylase complex to the pocket of retinoblastoma tumor suppressor family proteins found in limited discrete regions of the nucleus at growth arrest . Molecular and Cellular Biology . 21 . 8 . 2918–32 . Apr 2001 . 11283269 . 86920 . 10.1128/MCB.21.8.2918-2932.2001 .
• Fleischer TC, Yun UJ, Ayer DE . Identification and characterization of three new components of the mSin3A corepressor complex . Molecular and Cellular Biology . 23 . 10 . 3456–67 . May 2003 . 12724404 . 164750 . 10.1128/MCB.23.10.3456-3467.2003 .
• Meehan WJ, Samant RS, Hopper JE, Carrozza MJ, Shevde LA, Workman JL, Eckert KA, Verderame MF, Welch DR . Breast cancer metastasis suppressor 1 (BRMS1) forms complexes with retinoblastoma-binding protein 1 (RBP1) and the mSin3 histone deacetylase complex and represses transcription . The Journal of Biological Chemistry . 279 . 2 . 1562–9 . Jan 2004 . 14581478 . 10.1074/jbc.M307969200 . free .
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP . Large-scale characterization of HeLa cell nuclear phosphoproteins . Proceedings of the National Academy of Sciences of the United States of America . 101 . 33 . 12130–5 . Aug 2004 . 15302935 . 514446 . 10.1073/pnas.0404720101 . 2004PNAS..10112130B . free .
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes . Genome Research . 16 . 1 . 55–65 . Jan 2006 . 16344560 . 1356129 . 10.1101/gr.4039406 .
• Monroe DG, Secreto FJ, Hawse JR, Subramaniam M, Khosla S, Spelsberg TC . Estrogen receptor isoform-specific regulation of the retinoblastoma-binding protein 1 (RBBP1) gene: roles of AF1 and enhancer elements . The Journal of Biological Chemistry . 281 . 39 . 28596–604 . Sep 2006 . 16873370 . 10.1074/jbc.M605226200 . free .

Notes and References

1. Web site: Entrez Gene: ARID4A AT rich interactive domain 4A (RBP1-like).
2. Defeo-Jones D, Huang PS, Jones RE, Haskell KM, Vuocolo GA, Hanobik MG, Huber HE, Oliff A . Cloning of cDNAs for cellular proteins that bind to the retinoblastoma gene product . Nature . 352 . 6332 . 251–4 . Jul 1991 . 1857421 . 10.1038/352251a0 . 1991Natur.352..251D . 4357523 .
3. Otterson GA, Kratzke RA, Lin AY, Johnston PG, Kaye FJ . Alternative splicing of the RBP1 gene clusters in an internal exon that encodes potential phosphorylation sites . Oncogene . 8 . 4 . 949–57 . Apr 1993 . 8455946 .
4. Lai A, Lee JM, Yang WM, DeCaprio JA, Kaelin WG, Seto E, Branton PE . RBP1 recruits both histone deacetylase-dependent and -independent repression activities to retinoblastoma family proteins . Molecular and Cellular Biology . 19 . 10 . 6632–41 . Oct 1999 . 10490602 . 84642 . 10.1128/mcb.19.10.6632.