ARID3B explained

AT-rich interactive domain-containing protein 3B is a protein that in humans is encoded by the ARID3B gene.^[1]

Function

This gene encodes a member of the ARID (AT-rich interaction domain) family of DNA-binding proteins. The encoded protein is homologous with two proteins that bind to the retinoblastoma gene product, and also with the mouse Bright and Drosophila dead ringer proteins. A pseudogene on chromosome 1p31 exists for this gene. Members of the ARID family have roles in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation and possibly in chromatin structure modification.

Further reading

• Kortschak RD, Tucker PW, Saint R . ARID proteins come in from the desert . Trends in Biochemical Sciences . 25 . 6 . 294–9 . Jun 2000 . 10838570 . 10.1016/S0968-0004(00)01597-8 .
• Numata S, Claudio PP, Dean C, Giordano A, Croce CM . Bdp, a new member of a family of DNA-binding proteins, associates with the retinoblastoma gene product . Cancer Research . 59 . 15 . 3741–7 . Aug 1999 . 10446990 .
• Liao TT, Hsu WH, Ho CH, Hwang WL, Lan HY, Lo T, Chang CC, Tai SK, Yang MH . let-7 Modulates Chromatin Configuration and Target Gene Repression through Regulation of the ARID3B Complex . Cell Reports . 14 . 3 . 520–33 . 2016 . 26776511 . 10.1016/j.celrep.2015.12.064 . free .

Notes and References

1. Web site: Entrez Gene: ARID3B AT rich interactive domain 3B (BRIGHT-like).