ARID3A explained

AT-rich interactive domain-containing protein 3A is a protein that in humans is encoded by the ARID3A gene.^{[1] [2]}

Function

This gene encodes a member of the ARID (AT-rich interaction domain) family of DNA binding proteins. It was found by homology to the Drosophila dead ringer gene, which is important for normal embryogenesis. Other ARID family members have roles in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation, and possibly in chromatin structure modification.^[2]

Interactions

ARID3A has been shown to interact with:

• BTK,^[3] and
• E2F1^[4]

References

Further reading

• Kortschak RD, Tucker PW, Saint R . ARID proteins come in from the desert . Trends in Biochemical Sciences . 25 . 6 . 294–9 . Jun 2000 . 10838570 . 10.1016/S0968-0004(00)01597-8 .
• Suzuki M, Okuyama S, Okamoto S, Shirasuna K, Nakajima T, Hachiya T, Nojima H, Sekiya S, Oda K . A novel E2F binding protein with Myc-type HLH motif stimulates E2F-dependent transcription by forming a heterodimer . Oncogene . 17 . 7 . 853–65 . Aug 1998 . 9780002 . 10.1038/sj.onc.1202163 . 23588950 .
• Peeper DS, Shvarts A, Brummelkamp T, Douma S, Koh EY, Daley GQ, Bernards R . A functional screen identifies hDRIL1 as an oncogene that rescues RAS-induced senescence . Nature Cell Biology . 4 . 2 . 148–53 . Feb 2002 . 11812999 . 10.1038/ncb742 . 1874/15575 . 1392204 . free .
• Kaiwen M . [Involvement of E2FBP1, an ARID family member protein, in the p53 regulatory pathway] . Kōkūbyō Gakkai Zasshi. The Journal of the Stomatological Society, Japan . 69 . 2 . 152–61 . Jun 2002 . 12136662 . 10.5357/koubyou.69.152 . free .
• Goebel P, Montalbano A, Ayers N, Kompfner E, Dickinson L, Webb CF, Feeney AJ . High frequency of matrix attachment regions and cut-like protein x/CCAAT-displacement protein and B cell regulator of IgH transcription binding sites flanking Ig V region genes . Journal of Immunology . 169 . 5 . 2477–87 . Sep 2002 . 12193717 . 10.4049/jimmunol.169.5.2477 . free .
• Ma K, Araki K, Ichwan SJ, Suganuma T, Tamamori-Adachi M, Ikeda MA . E2FBP1/DRIL1, an AT-rich interaction domain-family transcription factor, is regulated by p53 . Molecular Cancer Research . 1 . 6 . 438–44 . Apr 2003 . 12692263 .
• Fukuyo Y, Mogi K, Tsunematsu Y, Nakajima T . E2FBP1/hDril1 modulates cell growth through downregulation of promyelocytic leukemia bodies . Cell Death and Differentiation . 11 . 7 . 747–59 . Jul 2004 . 15017387 . 10.1038/sj.cdd.4401412 . free .
• Nixon JC, Rajaiya JB, Ayers N, Evetts S, Webb CF . The transcription factor, Bright, is not expressed in all human B lymphocyte subpopulations . Cellular Immunology . 228 . 1 . 42–53 . Mar 2004 . 15203319 . 10.1016/j.cellimm.2004.03.004 .
• Rajaiya J, Nixon JC, Ayers N, Desgranges ZP, Roy AL, Webb CF . Induction of immunoglobulin heavy-chain transcription through the transcription factor Bright requires TFII-I . Molecular and Cellular Biology . 26 . 12 . 4758–68 . Jun 2006 . 16738337 . 1489113 . 10.1128/MCB.02009-05 .
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . Nov 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . free .
• Lin D, Ippolito GC, Zong RT, Bryant J, Koslovsky J, Tucker P . Bright/ARID3A contributes to chromatin accessibility of the immunoglobulin heavy chain enhancer . Molecular Cancer . 6 . 23 . 2007 . 17386101 . 1852116 . 10.1186/1476-4598-6-23 . free .
• Liao TT, Hsu WH, Ho CH, Hwang WL, Lan HY, Lo T, Chang CC, Tai SK, Yang MH . let-7 Modulates Chromatin Configuration and Target Gene Repression through Regulation of the ARID3B Complex . Cell Reports . 14 . 3 . 520–33 . January 2016 . 26776511. 10.1016/j.celrep.2015.12.064 . ARID3A was identified as let-7 target. Let-7i repressed ARID3A expression by binding to the 3′ UTR of the ARID3A transcript. In the absence of let-7, importin-9 facilitates the nuclear import of ARID3A, which then forms a complex with ARID3B. . free .

Notes and References

1. Kortschak RD, Reimann H, Zimmer M, Eyre HJ, Saint R, Jenne DE . The human dead ringer/bright homolog, DRIL1: cDNA cloning, gene structure, and mapping to D19S886, a marker on 19p13.3 that is strictly linked to the Peutz-Jeghers syndrome . Genomics . 51 . 2 . 288–92 . Jul 1998 . 9722953 . 10.1006/geno.1998.5259 .
2. Web site: Entrez Gene: ARID3A AT rich interactive domain 3A (BRIGHT-like).
3. Nixon JC, Rajaiya JB, Ayers N, Evetts S, Webb CF . The transcription factor, Bright, is not expressed in all human B lymphocyte subpopulations . Cellular Immunology . 228 . 1 . 42–53 . Mar 2004 . 15203319 . 10.1016/j.cellimm.2004.03.004 .
4. Suzuki M, Okuyama S, Okamoto S, Shirasuna K, Nakajima T, Hachiya T, Nojima H, Sekiya S, Oda K . A novel E2F binding protein with Myc-type HLH motif stimulates E2F-dependent transcription by forming a heterodimer . Oncogene . 17 . 7 . 853–65 . Aug 1998 . 9780002 . 10.1038/sj.onc.1202163 . 23588950 .