ARHGEF9 explained

See also: Collybistin. Rho guanine nucleotide exchange factor 9 is a protein that in humans is encoded by the ARHGEF9 gene.^{[1] [2]}

Function

ARHGEF9 belongs to a family of Rho-like GTPases that act as molecular switches by cycling from the active GTP-bound state to the inactive GDP-bound state. These proteins are key regulators of the actin cytoskeleton and are involved in cell signaling.[supplied by OMIM]^[3]

Interactions

ARHGEF9 has been shown to interact with GPHN^[4] and SMURF1.^[5]

Further reading

• Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S . Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions . Genome Res. . 14 . 9 . 1711–8 . 2004 . 15342556 . 515316 . 10.1101/gr.2435604 .
• Harvey K, Duguid IC, Alldred MJ, Beatty SE, Ward H, Keep NH, Lingenfelter SE, Pearce BR, Lundgren J, Owen MJ, Smart TG, Lüscher B, Rees MI, Harvey RJ . The GDP-GTP exchange factor collybistin: an essential determinant of neuronal gephyrin clustering . J. Neurosci. . 24 . 25 . 5816–26 . 2004 . 15215304 . 10.1523/JNEUROSCI.1184-04.2004 . 6729214 . free .
• Grosskreutz Y, Hermann A, Kins S, Fuhrmann JC, Betz H, Kneussel M . Identification of a gephyrin-binding motif in the GDP/GTP exchange factor collybistin . Biol. Chem. . 382 . 10 . 1455–62 . 2002 . 11727829 . 10.1515/BC.2001.179 . 2415901 .
• Kins S, Betz H, Kirsch J . Collybistin, a newly identified brain-specific GEF, induces submembrane clustering of gephyrin . Nat. Neurosci. . 3 . 1 . 22–9 . 2000 . 10607391 . 10.1038/71096 . 24878249 .

Notes and References

1. Reid T, Bathoorn A, Ahmadian MR, Collard JG . Identification and characterization of hPEM-2, a guanine nucleotide exchange factor specific for Cdc42 . J Biol Chem . 274 . 47 . 33587–93 . Dec 1999 . 10559246 . 10.1074/jbc.274.47.33587 . free .
2. Ishikawa K, Nagase T, Nakajima D, Seki N, Ohira M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O . Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro . DNA Res . 4 . 5 . 307–13 . Feb 1998 . 9455477 . 10.1093/dnares/4.5.307 . free .
3. Web site: Entrez Gene: ARHGEF9 Cdc42 guanine nucleotide exchange factor (GEF) 9.
4. Kins S, Betz H, Kirsch J . Collybistin, a newly identified brain-specific GEF, induces submembrane clustering of gephyrin . Nat. Neurosci. . 3 . 1 . 22–9 . 2000 . 10607391 . 10.1038/71096 . 24878249 .
5. Yamaguchi K, Ohara O, Ando A, Nagase T . Smurf1 directly targets hPEM-2, a GEF for Cdc42, via a novel combination of protein interaction modules in the ubiquitin-proteasome pathway . Biol. Chem. . 389 . 4 . 405–13 . Apr 2008 . 18208356 . 10.1515/BC.2008.036 . 27505034 .