ARHGEF9 explained

See also: Collybistin. Rho guanine nucleotide exchange factor 9 is a protein that in humans is encoded by the ARHGEF9 gene.[1] [2]

Function

ARHGEF9 belongs to a family of Rho-like GTPases that act as molecular switches by cycling from the active GTP-bound state to the inactive GDP-bound state. These proteins are key regulators of the actin cytoskeleton and are involved in cell signaling.[supplied by OMIM][3]

Interactions

ARHGEF9 has been shown to interact with GPHN[4] and SMURF1.[5]

Further reading

Notes and References

  1. Reid T, Bathoorn A, Ahmadian MR, Collard JG . Identification and characterization of hPEM-2, a guanine nucleotide exchange factor specific for Cdc42 . J Biol Chem . 274 . 47 . 33587–93 . Dec 1999 . 10559246 . 10.1074/jbc.274.47.33587 . free .
  2. Ishikawa K, Nagase T, Nakajima D, Seki N, Ohira M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O . Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro . DNA Res . 4 . 5 . 307–13 . Feb 1998 . 9455477 . 10.1093/dnares/4.5.307 . free .
  3. Web site: Entrez Gene: ARHGEF9 Cdc42 guanine nucleotide exchange factor (GEF) 9.
  4. Kins S, Betz H, Kirsch J . Collybistin, a newly identified brain-specific GEF, induces submembrane clustering of gephyrin . Nat. Neurosci. . 3 . 1 . 22–9 . 2000 . 10607391 . 10.1038/71096 . 24878249 .
  5. Yamaguchi K, Ohara O, Ando A, Nagase T . Smurf1 directly targets hPEM-2, a GEF for Cdc42, via a novel combination of protein interaction modules in the ubiquitin-proteasome pathway . Biol. Chem. . 389 . 4 . 405–13 . Apr 2008 . 18208356 . 10.1515/BC.2008.036 . 27505034 .