ARHGEF5 explained

Rho guanine nucleotide exchange factor 5 is a protein that in humans is encoded by the ARHGEF5 gene.^{[1] [2] [3]}

Rho GTPases play a fundamental role in numerous cellular processes initiated by extracellular stimuli that work through G protein-coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein may be involved in the control of cytoskeletal organization.

Further reading

• Snyder JT, Worthylake DK, Rossman KL . Structural basis for the selective activation of Rho GTPases by Dbl exchange factors. . Nat. Struct. Biol. . 9 . 6 . 468–75 . 2002 . 12006984 . 10.1038/nsb796 . 13161854 . etal.
• Wistow G, Bernstein SL, Wyatt MK . Expressed sequence tag analysis of adult human lens for the NEIBank Project: over 2000 non-redundant transcripts, novel genes and splice variants. . Mol. Vis. . 8 . 171–84 . 2002 . 12107413 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Hillier LW, Fulton RS, Fulton LA . The DNA sequence of human chromosome 7. . Nature . 424 . 6945 . 157–64 . 2003 . 12853948 . 10.1038/nature01782 . 2003Natur.424..157H . etal. free .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Umetsu DT, Dekruyff RH . Regulation of tolerance in the respiratory tract: TIM-1, hygiene, and the environment. . Ann. N. Y. Acad. Sci. . 1029 . 1. 88–93 . 2005 . 15681748 . 10.1196/annals.1309.012 . 38149688 .
• Benzinger A, Muster N, Koch HB . Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer. . Mol. Cell. Proteomics . 4 . 6 . 785–95 . 2005 . 15778465 . 10.1074/mcp.M500021-MCP200 . etal. free .
• Zhang Y, Wolf-Yadlin A, Ross PL . Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules. . Mol. Cell. Proteomics . 4 . 9 . 1240–50 . 2005 . 15951569 . 10.1074/mcp.M500089-MCP200 . etal. free .

Notes and References

1. Chan AM, McGovern ES, Catalano G, Fleming TP, Miki T . Expression cDNA cloning of a novel oncogene with sequence similarity to regulators of small GTP-binding proteins . Oncogene . 9 . 4 . 1057–63 . Apr 1994 . 8134109 .
2. Takai S, Chan AM, Yamada K, Miki T . Assignment of the human TIM proto-oncogene to 7q33→q35 . Cancer Genet Cytogenet . 83 . 1 . 87–9 . Oct 1995 . 7656213 . 10.1016/S0165-4608(95)00017-8 .
3. Web site: Entrez Gene: ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5.