ARHGEF2 explained

Rho guanine nucleotide exchange factor 2 is a protein that in humans is encoded by the ARHGEF2 gene.^{[1] [2] [3]}

Function

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein-coupled receptors. The encoded protein may form complex with G proteins and stimulate rho-dependent signals.

Interactions

ARHGEF2 has been shown to interact with PAK1.^[4]

Further reading

• Ehrhardt A, Ehrhardt GR, Guo X, Schrader JW . Ras and relatives--job sharing and networking keep an old family together . Exp. Hematol. . 30 . 10 . 1089–106 . 2002 . 12384139 . 10.1016/S0301-472X(02)00904-9 . free .
• Reddy AB, Chatterjee A, Rothblum LI, Black A, Busch H . Isolation and characterization of complementary DNA to proliferating cell nucleolar antigen P40 . Cancer Res. . 49 . 7 . 1763–7 . 1989 . 2466560 .
• Hartley JL, Temple GF, Brasch MA . DNA Cloning Using In Vitro Site-Specific Recombination . Genome Res. . 10 . 11 . 1788–95 . 2001 . 11076863 . 310948 . 10.1101/gr.143000 .
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A . Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs . Genome Res. . 11 . 3 . 422–35 . 2001 . 11230166 . 311072 . 10.1101/gr.GR1547R .
• Gao Y, Xing J, Streuli M, Leto TL, Zheng Y . Trp(56) of rac1 specifies interaction with a subset of guanine nucleotide exchange factors . J. Biol. Chem. . 276 . 50 . 47530–41 . 2002 . 11595749 . 10.1074/jbc.M108865200 . free .
• Krendel M, Zenke FT, Bokoch GM . Nucleotide exchange factor GEF-H1 mediates cross-talk between microtubules and the actin cytoskeleton . Nat. Cell Biol. . 4 . 4 . 294–301 . 2002 . 11912491 . 10.1038/ncb773 . 25681168 .
• Brajenovic M, Joberty G, Küster B, Bouwmeester T, Drewes G . Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network . J. Biol. Chem. . 279 . 13 . 12804–11 . 2004 . 14676191 . 10.1074/jbc.M312171200 . free .
• Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G . A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway . Nat. Cell Biol. . 6 . 2 . 97–105 . 2004 . 14743216 . 10.1038/ncb1086 . 11683986 .
• Zenke FT, Krendel M, DerMardirossian C, King CC, Bohl BP, Bokoch GM . p21-activated kinase 1 phosphorylates and regulates 14-3-3 binding to GEF-H1, a microtubule-localized Rho exchange factor . J. Biol. Chem. . 279 . 18 . 18392–400 . 2004 . 14970201 . 10.1074/jbc.M400084200 . free .
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP . Large-scale characterization of HeLa cell nuclear phosphoproteins . Proc. Natl. Acad. Sci. U.S.A. . 101 . 33 . 12130–5 . 2004 . 15302935 . 514446 . 10.1073/pnas.0404720101 . 2004PNAS..10112130B . free .
• Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T . Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization . Curr. Biol. . 14 . 16 . 1436–50 . 2004 . 15324660 . 10.1016/j.cub.2004.07.051 . 2371325 . free .
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A . From ORFeome to Biology: A Functional Genomics Pipeline . Genome Res. . 14 . 10B . 2136–44 . 2004 . 15489336 . 528930 . 10.1101/gr.2576704 .
• Callow MG, Zozulya S, Gishizky ML, Jallal B, Smeal T . PAK4 mediates morphological changes through the regulation of GEF-H1 . J. Cell Sci. . 118 . Pt 9 . 1861–72 . 2005 . 15827085 . 10.1242/jcs.02313 . free .
• Aijaz S, D'Atri F, Citi S, Balda MS, Matter K . Binding of GEF-H1 to the tight junction-associated adaptor cingulin results in inhibition of Rho signaling and G1/S phase transition . Dev. Cell . 8 . 5 . 777–86 . 2005 . 15866167 . 10.1016/j.devcel.2005.03.003 . free .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S . The LIFEdb database in 2006 . Nucleic Acids Res. . 34 . Database issue . D415–8 . 2006 . 16381901 . 1347501 . 10.1093/nar/gkj139 .

Notes and References

1. Ren Y, Li R, Zheng Y, Busch H . Cloning and characterization of GEF-H1, a microtubule-associated guanine nucleotide exchange factor for Rac and Rho GTPases . J Biol Chem . 273 . 52 . 34954–60 . Feb 1999 . 9857026 . 10.1074/jbc.273.52.34954 . free .
2. Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O . Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro . DNA Res . 5 . 3 . 169–76 . Dec 1998 . 9734811 . 10.1093/dnares/5.3.169 . free .
3. Web site: Entrez Gene: ARHGEF2 rho/rac guanine nucleotide exchange factor (GEF) 2.
4. Zenke FT, Krendel M, DerMardirossian C, King CC, Bohl BP, Bokoch GM . p21-activated kinase 1 phosphorylates and regulates 14-3-3 binding to GEF-H1, a microtubule-localized Rho exchange factor . J. Biol. Chem. . 279 . 18 . 18392–400 . Apr 2004 . 14970201 . 10.1074/jbc.M400084200 . free .