ARHGEF10 explained

The human ARHGEF10 gene encodes the protein Rho guanine nucleotide exchange factor 10.^{[1] [2] [3]}

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals.^[3]

Further reading

• Nakajima D . Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones . DNA Res. . 9 . 3 . 99–106 . 2003 . 12168954 . 10.1093/dnares/9.3.99 . Okazaki N . Yamakawa H . Kikuno . R . Ohara . O . Nagase . T . free .
• Jungerius BJ . An association screen of myelin-related genes implicates the chromosome 22q11 PIK4CA gene in schizophrenia . Molecular Psychiatry. 13. 11. 1060–8. 2008. 17893707 . 10.1038/sj.mp.4002080 . Hoogendoorn ML . Bakker SC . Van't Slot . R . Bardoel . A F . Ophoff . R A . Wijmenga . C . Kahn . R S . Sinke . R J . free .
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . Wagner L . Feingold EA . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Brandenberger R . Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation . Nat. Biotechnol. . 22 . 6 . 707–16 . 2005 . 15146197 . 10.1038/nbt971 . Wei H . Zhang S . Lei . Shirley . Murage . Jaji . Fisk . Gregory J . Li . Yan . Xu . Chunhui . Fang . Rixun . 27764390 .
• Verhoeven K . Slowed Conduction and Thin Myelination of Peripheral Nerves Associated with Mutant Rho Guanine-Nucleotide Exchange Factor 10 . Am. J. Hum. Genet. . 73 . 4 . 926–32 . 2003 . 14508709 . 10.1086/378159 . 1180612 . De Jonghe P . Van de Putte T . Nelis . Eva . Zwijsen . An . Verpoorten . Nathalie . De Vriendt . Els . Jacobs . An . Van Gerwen . Veerle .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proceedings of the National Academy of Sciences of the United States of America . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . Feingold EA . Grouse LH . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Ranta S . High-resolution mapping and transcript identification at the progressive epilepsy with mental retardation locus on chromosome 8p . Genome Res. . 7 . 9 . 887–96 . 1997 . 9314494 . 10.1101/gr.7.9.887. Lehesjoki AE . de Fatima Bonaldo M . Knowles . JA . Hirvasniemi . A . Ross . B . De Jong . PJ . Soares . MB . De La Chapelle . A . free .

Notes and References

1. Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O . Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro . DNA Res . 4 . 2 . 141–50 . Sep 1997 . 9205841 . 10.1093/dnares/4.2.141 . free .
2. Mohl M, Winkler S, Wieland T, Lutz S . Gef10--the third member of a Rho-specific guanine nucleotide exchange factor subfamily with unusual protein architecture . Naunyn-Schmiedeberg's Arch Pharmacol . 373 . 5 . 333–41 . Aug 2006 . 16896804 . 10.1007/s00210-006-0083-0 . 29822779 .
3. Web site: Entrez Gene: ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10.