ARHGAP4 explained

Rho GTPase-activating protein 4 is an enzyme that in humans is encoded by the ARHGAP4 gene.^{[1] [2]} It has been shown to regulate cell motility and axonal outgrowth in vitro.^[3]

Further reading

• Tribioli C, Mancini M, Plassart E . Isolation of new genes in distal Xq28: transcriptional map and identification of a human homologue of the ARD1 N-acetyl transferase of Saccharomyces cerevisiae . Hum. Mol. Genet. . 3 . 7 . 1061–7 . 1995 . 7981673 . 10.1093/hmg/3.7.1061 . etal.
• Nagase T, Seki N, Tanaka A . Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1 . DNA Res. . 2 . 4 . 167–74, 199–210 . 1996 . 8590280 . 10.1093/dnares/2.4.167 . etal.
• Brenner V, Nyakatura G, Rosenthal A, Platzer M . Genomic organization of two novel genes on human Xq28: compact head to head arrangement of IDH gamma and TRAP delta is conserved in rat and mouse . Genomics . 44 . 1 . 8–14 . 1997 . 9286695 . 10.1006/geno.1997.4822 .
• Zuber J, Tchernitsa OI, Hinzmann B . A genome-wide survey of RAS transformation targets . Nat. Genet. . 24 . 2 . 144–52 . 2000 . 10655059 . 10.1038/72799 . 21887748 . etal.
• Hartley JL, Temple GF, Brasch MA . DNA Cloning Using In Vitro Site-Specific Recombination . Genome Res. . 10 . 11 . 1788–95 . 2001 . 11076863 . 10.1101/gr.143000 . 310948 .
• Simpson JC, Wellenreuther R, Poustka A . Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing . EMBO Rep. . 1 . 3 . 287–92 . 2001 . 11256614 . 10.1093/embo-reports/kvd058 . 1083732 . etal.
• Demura M, Takeda Y, Yoneda T . Two novel types of contiguous gene deletion of the AVPR2 and ARHGAP4 genes in unrelated Japanese kindreds with nephrogenic diabetes insipidus . Hum. Mutat. . 19 . 1 . 23–9 . 2002 . 11754100 . 10.1002/humu.10011 . 21379792 . etal. free .
• Christerson LB, Gallagher E, Vanderbilt CA . p115 Rho GTPase activating protein interacts with MEKK1 . J. Cell. Physiol. . 192 . 2 . 200–8 . 2002 . 12115726 . 10.1002/jcp.10125 . 33717402 . etal.
• Foletta VC, Brown FD, Young WS . Cloning of rat ARHGAP4/C1, a RhoGAP family member expressed in the nervous system that colocalizes with the Golgi complex and microtubules . Brain Res. Mol. Brain Res. . 107 . 1 . 65–79 . 2003 . 12414125 . 10.1016/S0169-328X(02)00448-5 .
• Soderling SH, Binns KL, Wayman GA . The WRP component of the WAVE-1 complex attenuates Rac-mediated signalling . Nat. Cell Biol. . 4 . 12 . 970–5 . 2003 . 12447388 . 10.1038/ncb886 . 1423222 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Katoh M, Katoh M . FNBP2 gene on human chromosome 1q32.1 encodes ARHGAP family protein with FCH, FBH, RhoGAP and SH3 domains . Int. J. Mol. Med. . 11 . 6 . 791–7 . 2004 . 12736724 . 10.3892/ijmm.11.6.791.
• Wiemann S, Arlt D, Huber W . From ORFeome to Biology: A Functional Genomics Pipeline . Genome Res. . 14 . 10B . 2136–44 . 2004 . 15489336 . 10.1101/gr.2576704 . 528930 . etal.
• Mehrle A, Rosenfelder H, Schupp I . The LIFEdb database in 2006 . Nucleic Acids Res. . 34 . Database issue . D415–8 . 2006 . 16381901 . 10.1093/nar/gkj139 . 1347501 . etal.

Notes and References

1. Tribioli C, Droetto S, Bione S, Cesareni G, Torrisi MR, Lotti LV, Lanfrancone L, Toniolo D, Pelicci P . An X chromosome-linked gene encoding a protein with characteristics of a rhoGAP predominantly expressed in hematopoietic cells . Proc Natl Acad Sci U S A . 93 . 2 . 695–9 . Mar 1996 . 8570618 . 40115 . 10.1073/pnas.93.2.695 . 1996PNAS...93..695T . free .
2. Web site: Entrez Gene: ARHGAP4 Rho GTPase activating protein 4.
3. Vogt . DL . Gray . CD . Young Ws . 3rd . Orellana . SA . Malouf . AT . ARHGAP4 is a novel RhoGAP that mediates inhibition of cell motility and axon outgrowth . Molecular and Cellular Neurosciences . 36 . 3 . 332–42 . 2007 . 17804252 . 2111057 . 10.1016/j.mcn.2007.07.004 .