ARFRP1 explained

ADP-ribosylation factor-related protein 1 is a protein that in humans is encoded by the ARFRP1 gene.^{[1] [2]}

Function

The protein encoded by this gene is a membrane-associated GTP-ase and localizes to the plasma membrane. It is related to the ADP-ribosylation factor (ARF) and ARF-like (ARL) genes. The gene is located in a gene cluster that includes the a gene (M68) that is overexpressed in some tumors.^[2]

Interactions

ARFRP1 has been shown to interact with PSCD1.^[3]

Further reading

• Zahn C, Hommel A, Lu L . Knockout of Arfrp1 leads to disruption of ARF-like1 (ARL1) targeting to the trans-Golgi in mouse embryos and HeLa cells. . Mol. Membr. Biol. . 23 . 6 . 475–85 . 2007 . 17127620 . 10.1080/09687860600840100 . 22778359 . etal.
• Shin HW, Kobayashi H, Kitamura M . Roles of ARFRP1 (ADP-ribosylation factor-related protein 1) in post-Golgi membrane trafficking. . J. Cell Sci. . 118 . Pt 17 . 4039–48 . 2005 . 16129887 . 10.1242/jcs.02524 . etal. free .
• Barrios-Rodiles M, Brown KR, Ozdamar B . High-throughput mapping of a dynamic signaling network in mammalian cells. . Science . 307 . 5715 . 1621–5 . 2005 . 15761153 . 10.1126/science.1105776 . 2005Sci...307.1621B . 39457788 . etal.
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Behnia R, Panic B, Whyte JR, Munro S . Targeting of the Arf-like GTPase Arl3p to the Golgi requires N-terminal acetylation and the membrane protein Sys1p. . Nat. Cell Biol. . 6 . 5 . 405–13 . 2004 . 15077113 . 10.1038/ncb1120 . 22954283 .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Deloukas P, Matthews LH, Ashurst J . The DNA sequence and comparative analysis of human chromosome 20. . Nature . 414 . 6866 . 865–71 . 2002 . 11780052 . 10.1038/414865a . 2001Natur.414..865D . etal. free .
• Coppola T, Magnin-Luthi S, Perret-Menoud V . Direct interaction of the Rab3 effector RIM with Ca2+ channels, SNAP-25, and synaptotagmin. . J. Biol. Chem. . 276 . 35 . 32756–62 . 2001 . 11438518 . 10.1074/jbc.M100929200 . etal. free .
• Bai C, Connolly B, Metzker ML . Overexpression of M68/DcR3 in human gastrointestinal tract tumors independent of gene amplification and its location in a four-gene cluster. . Proc. Natl. Acad. Sci. U.S.A. . 97 . 3 . 1230–5 . 2000 . 10655513 . 10.1073/pnas.97.3.1230 . 15578 . 2000PNAS...97.1230B . etal. free .
• Schürmann A, Schmidt M, Asmus M . The ADP-ribosylation factor (ARF)-related GTPase ARF-related protein binds to the ARF-specific guanine nucleotide exchange factor cytohesin and inhibits the ARF-dependent activation of phospholipase D. . J. Biol. Chem. . 274 . 14 . 9744–51 . 1999 . 10092663 . 10.1074/jbc.274.14.9744 . etal. free .

Notes and References

1. Schurmann A, Massmann S, Joost HG . ARP is a plasma membrane-associated Ras-related GTPase with remote similarity to the family of ADP-ribosylation factors . J Biol Chem . 270 . 51 . 30657–63 . Jan 1996 . 8530503 . 10.1074/jbc.270.51.30657 . free .
2. Web site: Entrez Gene: ARFRP1 ADP-ribosylation factor related protein 1.
3. Schürmann A, Schmidt M, Asmus M, Bayer S, Fliegert F, Koling S, Massmann S, Schilf C, Subauste MC, Voss M, Jakobs KH, Joost HG . The ADP-ribosylation factor (ARF)-related GTPase ARF-related protein binds to the ARF-specific guanine nucleotide exchange factor cytohesin and inhibits the ARF-dependent activation of phospholipase D . J. Biol. Chem. . 274 . 14 . 9744–51 . April 1999 . 10092663 . 10.1074/jbc.274.14.9744 . free .