ARFIP2 explained

Arfaptin-2 is a protein that in humans is encoded by the ARFIP2 gene.^{[1] [2] [3]}

Interactions

ARFIP2 has been shown to interact with Arf6,^{[4] [5]} ARF3, ARF5^{[2] [5]} and RAC1.^{[5] [6]}

Further reading

• D'Souza-Schorey C, Boshans RL, McDonough M, Stahl PD, Van Aelst L . A role for POR1, a Rac1-interacting protein, in ARF6-mediated cytoskeletal rearrangements . The EMBO Journal . 16 . 17 . 5445–54 . September 1997 . 9312003 . 1170175 . 10.1093/emboj/16.17.5445 .
• Tarricone C, Xiao B, Justin N, Walker PA, Rittinger K, Gamblin SJ, Smerdon SJ . The structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways . Nature . 411 . 6834 . 215–9 . May 2001 . 11346801 . 10.1038/35075620 . 4324211 .
• Shin OH, Exton JH . Differential binding of arfaptin 2/POR1 to ADP-ribosylation factors and Rac1 . Biochemical and Biophysical Research Communications . 285 . 5 . 1267–73 . August 2001 . 11478794 . 10.1006/bbrc.2001.5330 .
• Peters PJ, Ning K, Palacios F, Boshans RL, Kazantsev A, Thompson LM, Woodman B, Bates GP, D'Souza-Schorey C . Arfaptin 2 regulates the aggregation of mutant huntingtin protein . Nature Cell Biology . 4 . 3 . 240–5 . March 2002 . 11854752 . 10.1038/ncb761 . 10881911 .
• Lu L, Hong W . Interaction of Arl1-GTP with GRIP domains recruits autoantigens Golgin-97 and Golgin-245/p230 onto the Golgi . Molecular Biology of the Cell . 14 . 9 . 3767–81 . September 2003 . 12972563 . 196566 . 10.1091/mbc.E03-01-0864 .
• Rangone H, Pardo R, Colin E, Girault JA, Saudou F, Humbert S . Phosphorylation of arfaptin 2 at Ser260 by Akt Inhibits PolyQ-huntingtin-induced toxicity by rescuing proteasome impairment . The Journal of Biological Chemistry . 280 . 23 . 22021–8 . June 2005 . 15809304 . 10.1074/jbc.M407528200 . free .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . October 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .

Notes and References

1. Van Aelst L, Joneson T, Bar-Sagi D . Identification of a novel Rac1-interacting protein involved in membrane ruffling . The EMBO Journal . 15 . 15 . 3778–86 . August 1996 . 8670882 . 452058 . 10.1002/j.1460-2075.1996.tb00751.x.
2. Kanoh H, Williger BT, Exton JH . Arfaptin 1, a putative cytosolic target protein of ADP-ribosylation factor, is recruited to Golgi membranes . The Journal of Biological Chemistry . 272 . 9 . 5421–9 . February 1997 . 9038142 . 10.1074/jbc.272.9.5421 . free.
3. Web site: Entrez Gene: ARFIP2 ADP-ribosylation factor interacting protein 2 (arfaptin 2).
4. D'Souza-Schorey C, Boshans RL, McDonough M, Stahl PD, Van Aelst L . A role for POR1, a Rac1-interacting protein, in ARF6-mediated cytoskeletal rearrangements . The EMBO Journal . 16 . 17 . 5445–54 . September 1997 . 9312003 . 1170175 . 10.1093/emboj/16.17.5445 .
5. Shin OH, Exton JH . Differential binding of arfaptin 2/POR1 to ADP-ribosylation factors and Rac1 . Biochemical and Biophysical Research Communications . 285 . 5 . 1267–73 . August 2001 . 11478794 . 10.1006/bbrc.2001.5330 .
6. Tarricone C, Xiao B, Justin N, Walker PA, Rittinger K, Gamblin SJ, Smerdon SJ . The structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways . Nature . 411 . 6834 . 215–9 . May 2001 . 11346801 . 10.1038/35075620 . 4324211 .