ARFGEF2 explained

Brefeldin A-inhibited guanine nucleotide-exchange protein 2 is a protein that in humans is encoded by the ARFGEF2 gene.^{[1] [2]}

Function

ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP and is involved in Golgi transport. It contains a Sec7 domain, which may be responsible for its guanine-nucleotide exchange activity and also brefeldin A inhibition.^[2]

Interactions

ARFGEF2 has been shown to interact with ARFGEF1,^[3] PRKAR1A^[4] and PRKAR2A.^[4]

Further reading

• Yamaji R, Adamik R, Takeda K, Togawa A, Pacheco-Rodriguez G, Ferrans VJ, Moss J, Vaughan M . Identification and localization of two brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors in a macromolecular complex . Proceedings of the National Academy of Sciences of the United States of America . 97 . 6 . 2567–72 . Mar 2000 . 10716990 . 15969 . 10.1073/pnas.97.6.2567 . 2000PNAS...97.2567Y . free .
• Kamei Y, Takeda Y, Teramoto K, Tsutsumi O, Taketani Y, Watanabe K . Human NB-2 of the contactin subgroup molecules: chromosomal localization of the gene (CNTN5) and distinct expression pattern from other subgroup members . Genomics . 69 . 1 . 113–9 . Oct 2000 . 11013081 . 10.1006/geno.2000.6310 .
• Book: Pacheco-Rodriguez G, Moss J, Vaughan M . G Protein Pathways - Part C, Effector Mechanisms . BIG1 and BIG2: brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors . Methods in Enzymology . 345 . 397–404 . 2002 . 11665623 . 10.1016/S0076-6879(02)45032-X . 9780121822460 .
• Shinotsuka C, Yoshida Y, Kawamoto K, Takatsu H, Nakayama K . Overexpression of an ADP-ribosylation factor-guanine nucleotide exchange factor, BIG2, uncouples brefeldin A-induced adaptor protein-1 coat dissociation and membrane tubulation . The Journal of Biological Chemistry . 277 . 11 . 9468–73 . Mar 2002 . 11777925 . 10.1074/jbc.M112427200 . free .
• Shinotsuka C, Waguri S, Wakasugi M, Uchiyama Y, Nakayama K . Dominant-negative mutant of BIG2, an ARF-guanine nucleotide exchange factor, specifically affects membrane trafficking from the trans-Golgi network through inhibiting membrane association of AP-1 and GGA coat proteins . Biochemical and Biophysical Research Communications . 294 . 2 . 254–60 . Jun 2002 . 12051703 . 10.1016/S0006-291X(02)00456-4 .
• Li H, Adamik R, Pacheco-Rodriguez G, Moss J, Vaughan M . Protein kinase A-anchoring (AKAP) domains in brefeldin A-inhibited guanine nucleotide-exchange protein 2 (BIG2) . Proceedings of the National Academy of Sciences of the United States of America . 100 . 4 . 1627–32 . Feb 2003 . 12571360 . 149883 . 10.1073/pnas.0337678100 . 2003PNAS..100.1627L . free .
• Sheen VL, Ganesh VS, Topcu M, Sebire G, Bodell A, Hill RS, Grant PE, Shugart YY, Imitola J, Khoury SJ, Guerrini R, Walsh CA . Mutations in ARFGEF2 implicate vesicle trafficking in neural progenitor proliferation and migration in the human cerebral cortex . Nature Genetics . 36 . 1 . 69–76 . Jan 2004 . 14647276 . 10.1038/ng1276 . free .
• Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM . Functional proteomics mapping of a human signaling pathway . Genome Research . 14 . 7 . 1324–32 . Jul 2004 . 15231748 . 442148 . 10.1101/gr.2334104 .
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP . Large-scale characterization of HeLa cell nuclear phosphoproteins . Proceedings of the National Academy of Sciences of the United States of America . 101 . 33 . 12130–5 . Aug 2004 . 15302935 . 514446 . 10.1073/pnas.0404720101 . 2004PNAS..10112130B . free .
• Xu KF, Shen X, Li H, Pacheco-Rodriguez G, Moss J, Vaughan M . Interaction of BIG2, a brefeldin A-inhibited guanine nucleotide-exchange protein, with exocyst protein Exo70 . Proceedings of the National Academy of Sciences of the United States of America . 102 . 8 . 2784–9 . Feb 2005 . 15705715 . 549493 . 10.1073/pnas.0409871102 . 2005PNAS..102.2784X . free .
• Lu J, Tiao G, Folkerth R, Hecht J, Walsh C, Sheen V . Overlapping expression of ARFGEF2 and Filamin A in the neuroependymal lining of the lateral ventricles: insights into the cause of periventricular heterotopia . The Journal of Comparative Neurology . 494 . 3 . 476–84 . Jan 2006 . 16320251 . 10.1002/cne.20806 . 16527134 .
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . Nov 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .
• Islam A, Shen X, Hiroi T, Moss J, Vaughan M, Levine SJ . The brefeldin A-inhibited guanine nucleotide-exchange protein, BIG2, regulates the constitutive release of TNFR1 exosome-like vesicles . The Journal of Biological Chemistry . 282 . 13 . 9591–9 . Mar 2007 . 17276987 . 10.1074/jbc.M607122200 . free .
• Kuroda F, Moss J, Vaughan M . Regulation of brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1) and BIG2 activity via PKA and protein phosphatase 1gamma . Proceedings of the National Academy of Sciences of the United States of America . 104 . 9 . 3201–6 . Feb 2007 . 17360629 . 1805514 . 10.1073/pnas.0611696104 . 2007PNAS..104.3201K . free .

Notes and References

1. Togawa A, Morinaga N, Ogasawara M, Moss J, Vaughan M . Purification and cloning of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP-ribosylation factors . The Journal of Biological Chemistry . 274 . 18 . 12308–15 . Apr 1999 . 10212200 . 10.1074/jbc.274.18.12308 . free .
2. Web site: Entrez Gene: ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited).
3. Yamaji R, Adamik R, Takeda K, Togawa A, Pacheco-Rodriguez G, Ferrans VJ, Moss J, Vaughan M . Identification and localization of two brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors in a macromolecular complex . Proceedings of the National Academy of Sciences of the United States of America . 97 . 6 . 2567–72 . Mar 2000 . 10716990 . 15969 . 10.1073/pnas.97.6.2567 . 2000PNAS...97.2567Y . free .
4. Li H, Adamik R, Pacheco-Rodriguez G, Moss J, Vaughan M . Protein kinase A-anchoring (AKAP) domains in brefeldin A-inhibited guanine nucleotide-exchange protein 2 (BIG2) . Proceedings of the National Academy of Sciences of the United States of America . 100 . 4 . 1627–32 . Feb 2003 . 12571360 . 149883 . 10.1073/pnas.0337678100 . 2003PNAS..100.1627L . free .