AR-A000002 explained

AR-A000002 is a drug which is one of the first compounds developed to act as a selective antagonist for the serotonin receptor 5-HT1B,[1] with approximately 10x selectivity for 5-HT1B over the closely related 5-HT1D receptor.[2] It has been shown to produce sustained increases in levels of serotonin in the brain, and has anxiolytic effects in animal studies.[3] [4]

Notes and References

  1. Hudzik TJ, Yanek M, Porrey T, Evenden J, Paronis C, Mastrangelo M, Ryan C, Ross S, Stenfors C . 6 . Behavioral pharmacology of AR-A000002, a novel, selective 5-hydroxytryptamine(1B) antagonist . The Journal of Pharmacology and Experimental Therapeutics . 304 . 3 . 1072–84 . March 2003 . 12604684 . 10.1124/jpet.102.045468 . 20463714 .
  2. Ahlgren C, Eriksson A, Tellefors P, Ross SB, Stenfors C, Malmberg A . In vitro characterization of AR-A000002, a novel 5-hydroxytryptamine(1B) autoreceptor antagonist . European Journal of Pharmacology . 499 . 1–2 . 67–75 . September 2004 . 15363952 . 10.1016/j.ejphar.2004.07.067 .
  3. Stenfors C, Ahlgren C, Yu H, Wedén M, Larsson LG, Ross SB . Effects of long-term administration of the 5-hydroxytryptamine1B receptor antagonist AR-A000002 to guinea pigs . Psychopharmacology . 172 . 3 . 333–40 . March 2004 . 14652708 . 10.1007/s00213-003-1667-8 . 25130658 .
  4. Stenfors C, Hallerbäck T, Larsson LG, Wallsten C, Ross SB . Pharmacology of a novel selective 5-hydroxytryptamine1B receptor antagonist, AR-A000002 . Naunyn-Schmiedeberg's Archives of Pharmacology . 369 . 3 . 330–7 . March 2004 . 14758468 . 10.1007/s00210-004-0866-0 . 21075322 .

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