Aquaporin-6 Explained

Aquaporin-6, (AQP-6) also known as kidney-specific aquaporin is a protein in humans that is encoded by the AQP6 gene.^[1]

The protein encoded by this gene is an aquaporin protein, which functions as a water channel in cells. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). This protein is specific for the kidney. This gene and related family members AQP0, AQP2, and AQP5 reside in a cluster on chromosome 12q13.^[1]

Further reading

• Ikeda M, Beitz E, Kozono D, Guggino WB, Agre P, Yasui M . Characterization of aquaporin-6 as a nitrate channel in mammalian cells. Requirement of pore-lining residue threonine 63 . The Journal of Biological Chemistry . 277 . 42 . 39873–9 . Oct 2002 . 12177001 . 10.1074/jbc.M207008200 . free.
• Ma T, Yang B, Umenishi F, Verkman AS . Closely spaced tandem arrangement of AQP2, AQP5, and AQP6 genes in a 27-kilobase segment at chromosome locus 12q13 . Genomics . 43 . 3 . 387–9 . Aug 1997 . 9268644 . 10.1006/geno.1997.4836 .
• Ishiyama G, Lopez IA, Beltran-Parrazal L, Ishiyama A . Immunohistochemical localization and mRNA expression of aquaporins in the macula utriculi of patients with Meniere's disease and acoustic neuroma . Cell and Tissue Research . 340 . 3 . 407–19 . Jun 2010 . 20461409 . 2882038 . 10.1007/s00441-010-0975-7 .
• Wang W, Hart PS, Piesco NP, Lu X, Gorry MC, Hart TC . Aquaporin expression in developing human teeth and selected orofacial tissues . Calcified Tissue International . 72 . 3 . 222–7 . Mar 2003 . 12522663 . 10.1007/s00223-002-1014-9 . 24539238 .
• Yusenko MV, Zubakov D, Kovacs G . Gene expression profiling of chromophobe renal cell carcinomas and renal oncocytomas by Affymetrix GeneChip using pooled and individual tumours . International Journal of Biological Sciences . 5 . 6 . 517–27 . 2009 . 10.7150/ijbs.5.517 . 19680475 . 2726578 .
• Ma T, Yang B, Kuo WL, Verkman AS . cDNA cloning and gene structure of a novel water channel expressed exclusively in human kidney: evidence for a gene cluster of aquaporins at chromosome locus 12q13 . Genomics . 35 . 3 . 543–50 . Aug 1996 . 8812490 . 10.1006/geno.1996.0396 .

Notes and References

1. Web site: Entrez Gene: Aquaporin 6, kidney specific. 2012-04-10.