APPBP2 explained

Amyloid protein-binding protein 2 is a protein that in humans is encoded by the APPBP2 gene.^{[1] [2]}

The protein encoded by this gene interacts with microtubules and is functionally associated with beta-amyloid precursor protein transport and/or processing. The beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. This gene has been found to be highly expressed in breast cancer. Multiple polyadenylation sites have been found for this gene.^[3]

Interactions

APPBP2 has been shown to interact with Amyloid precursor protein.

Notes and References

1. Zheng P, Eastman J, Vande Pol S, Pimplikar SW . PAT1, a microtubule-interacting protein, recognizes the basolateral sorting signal of amyloid precursor protein . Proc Natl Acad Sci U S A . 95 . 25 . 14745–50 . Jan 1999 . 9843960 . 24520 . 10.1073/pnas.95.25.14745 . free .
2. Web site: Entrez Gene: APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2.
3. Web site: Entrez Gene: APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2.