APP-FUBINACA explained

APP-FUBINACA is an indazole-based synthetic cannabinoid that has been sold online as a designer drug.^[1] Pharmacological testing showed APP-FUBINACA to have only moderate affinity for the CB₁ receptor, with a Ki of 708 nM, while its EC₅₀ was not tested.^[2] It contains a phenylalanine amino acid residue in its structure.^[3]

Legality

Sweden's public health agency suggested to classify APP-FUBINACA as hazardous substance on March 24, 2015.^[4]

See also

• 5F-AB-PINACA
• 5F-ADB
• 5F-AMB
• 5F-APINACA
• AB-FUBINACA
• AB-CHFUPYCA
• AB-CHMINACA
• AB-PINACA
• ADB-CHMINACA
• ADB-FUBINACA
• ADB-PINACA
• ADBICA
• APICA
• APINACA
• APP-BINACA^[5]
• BMS-F
• MDMB-CHMICA
• MDMB-FUBINACA
• PX-1
• PX-2
• PX-3

Notes and References

1. Web site: APP-FUBINACA . Cayman Chemical . 15 July 2015.
2. WO . 2009106982 . Indazole derivatives . Buchler IP, Hayes MJ, Hedge SG, Hockerman SL, Jones DL, Kortum SW, Rico JG, Tenbrink RE, Wu KK . Pfizer Inc . 3 September 2009 .
3. News: Evelyn . Alex . HHC (Hexahydrocannabinol) . 19 December 2021.
4. Web site: Fler ämnen föreslås bli klassade som narkotika eller hälsofarlig vara . Folkhälsomyndigheten . 16 July 2015.
5. Cannaert A, Sparkes E, Pike E, Luo JL, Fang A, Kevin RC, Ellison R, Gerona R, Banister SD, Stove CP . 6 . in Vitro Cannabinoid Receptor 1 Activity of Recently Detected Synthetic Cannabinoids 4F-MDMB-BICA, 5F-MPP-PICA, MMB-4en-PICA, CUMYL-CBMICA, ADB-BINACA, APP-BINACA, 4F-MDMB-BINACA, MDMB-4en-PINACA, A-CHMINACA, 5F-AB-P7AICA, 5F-MDMB-P7AICA, and 5F-AP7AICA . ACS Chemical Neuroscience . 11 . 24 . 4434–4446 . December 2020 . 33253529 . 10.1021/acschemneuro.0c00644 . 227246346 .