APOA1BP explained

Apolipoprotein A-I-binding protein also known as APOA1BP is a protein that in humans is encoded by the APOA1BP gene.[1] Progressive encephalopathy with brain edema and/or leukoencephalopathy-1 (PEBEL-1), a rare, lethal, neurometabolic disorder, is caused by mutation in NAXE gene (APOA1BP being its former name).[2]

Structure

APOA1BP gene is located on chromosome 1, with its specific location being 1q22. The gene contains 6 exons,[3] 5 introns, and spans 2.5 kb. Expression is ubiquitous across all human tissues, with highest observed in kidney, heart, liver, testis, thyroid gland, adrenal gland. APOA1BP contains Yje_FN domain.[4]

Function

APOA1BP binds to APOA1, APOA2, and high-density lipoprotein (HDL).[1] In addition, APOA1BP appears to play a role in sperm capacitation.[5] It has been demonstrated that APOA1BP is involved in angiogenesis regulation, by accelerating cholesterol efflux from endothelial cells to HDL.[6] [7] It is known that zebrafish APOA1BP ortholog Aibp is involved in angiogenesis regulation. The protein was also shown to be involved in atherosclerosis protection.

Notes and References

  1. Ritter M, Buechler C, Boettcher A, Barlage S, Schmitz-Madry A, Orsó E, Bared SM, Schmiedeknecht G, Baehr CH, Fricker G, Schmitz G . Cloning and characterization of a novel apolipoprotein A-I binding protein, AI-BP, secreted by cells of the kidney proximal tubules in response to HDL or ApoA-I . Genomics . 79 . 5 . 693–702 . May 2002 . 11991719 . 10.1006/geno.2002.6761 .
  2. Chiu . Li-Wei . Lin . Sheng-Shing . Chen . Chieh-Ho . Lin . Chien-Heng . Lee . Ni-Chung . Hong . Syuan-Yu . Chou . I.-Ching . Lin . Chien-Lin . Yang . Pei-Yu . 2021-10-22 . NAXE gene mutation-related progressive encephalopathy: A case report and literature review . Medicine . en-US . 100 . 42 . e27548 . 10.1097/MD.0000000000027548 . 8542128 . 34678889.
  3. Web site: NAXE NAD(P)HX epimerase [Homo sapiens (human)] - Gene - NCBI ]. 2024-03-28 . www.ncbi.nlm.nih.gov.
  4. Rudolph . C. . Sigruener . A. . Hartmann . A. . Orso . E. . Bals-Pratsch . M. . Gronwald . W. . Seifert . B. . Kalbitzer . H. R. . Verdorfer . I. . Luetjens . C. M. . Ortmann . O. . Bornstein . S. R. . Schmitz . G. . May 2007 . ApoA-I-binding protein (AI-BP) and its homologues hYjeF_N2 and hYjeF_N3 comprise the YjeF_N domain protein family in humans with a role in spermiogenesis and oogenesis . Hormone and Metabolic Research . 39 . 5 . 322–335 . 10.1055/s-2007-977699 . 0018-5043 . 17533573.
  5. Jha KN, Shumilin IA, Digilio LC, Chertihin O, Zheng H, Schmitz G, Visconti PE, Flickinger CJ, Minor W, Herr JC . Biochemical and Structural Characterization of Apolipoprotein A-I Binding Protein, a Novel Phosphoprotein with a Potential Role in Sperm Capacitation . Endocrinology . 149 . 5 . 2108–20 . May 2008 . 18202122 . 2329272 . 10.1210/en.2007-0582 .
  6. Fang . Longhou . Choi . Soo-Ho . Baek . Ji Sun . Liu . Chao . Almazan . Felicidad . Ulrich . Florian . Wiesner . Philipp . Taleb . Adam . Deer . Elena . Pattison . Jennifer . Torres-Vázquez . Jesús . Li . Andrew C. . Miller . Yury I. . 2013-06-06 . Control of angiogenesis by AIBP-mediated cholesterol efflux . Nature . 498 . 7452 . 118–122 . 10.1038/nature12166 . 1476-4687 . 3760669 . 23719382. 2013Natur.498..118F .
  7. Schneider . Dina A. . Choi . Soo-Ho . Agatisa-Boyle . Colin . Zhu . Laurence . Kim . Jungsu . Pattison . Jennifer . Sears . Dorothy D. . Gordts . PhilipL.S.M. . Fang . Longhou . Miller . Yury I. . 2018 . AIBP protects against metabolic abnormalities and atherosclerosis . Journal of Lipid Research . 59 . 5 . 854–863 . 10.1194/jlr.m083618 . 0022-2275 . 5928435 . 29559522 . free.

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