APC internal ribosome entry site (IRES) explained

APC internal ribosome entry site (IRES)
Symbol:IRES_APC
Rfam:RF00462
Rna Type:Cis-reg
IRES
Tax Domain:Eukaryota

The APC internal ribosome entry site (IRES) is an RNA element which is located in the coding sequence of the APC gene. APC is a tumour suppressor gene which is associated with the inherited disease adenomatous polyposis coli (APC). It is thought that IRES-mediated translation of APC is important for an apoptotic cascade.[1]

Notes and References

  1. Heppner Goss K, Trzepacz C, Tuohy TM, Groden J . Attenuated APC alleles produce functional protein from internal translation initiation . Proceedings of the National Academy of Sciences of the United States of America . 99 . 12 . 8161–8166 . June 2002 . 12034871 . 123038 . 10.1073/pnas.112072199 . free .

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