APBB2 explained

Amyloid beta A4 precursor protein-binding family B member 2 is a protein that in humans is encoded by the APBB2 gene.^{[1] [2]}

The protein encoded by this gene interacts with the cytoplasmic domains of amyloid beta (A4) precursor protein and amyloid beta (A4) precursor-like protein 2. This protein contains two phosphotyrosine binding (PTB) domains, which are thought to function in signal transduction.^[3]

Further reading

• Guénette SY, Chen J, Jondro PD, Tanzi RE . Association of a novel human FE65-like protein with the cytoplasmic domain of the beta-amyloid precursor protein . Proc. Natl. Acad. Sci. U.S.A. . 93 . 20 . 10832–7 . 1996 . 8855266 . 10.1073/pnas.93.20.10832 . 38241 . 1996PNAS...9310832G . free .
• Bruni P, Minopoli G, Brancaccio T . Fe65, a ligand of the Alzheimer's beta-amyloid precursor protein, blocks cell cycle progression by down-regulating thymidylate synthase expression . J. Biol. Chem. . 277 . 38 . 35481–8 . 2002 . 12089154 . 10.1074/jbc.M205227200 . etal. free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Chang Y, Tesco G, Jeong WJ . Generation of the beta-amyloid peptide and the amyloid precursor protein C-terminal fragment gamma are potentiated by FE65L1 . J. Biol. Chem. . 278 . 51 . 51100–7 . 2004 . 14527950 . 10.1074/jbc.M309561200 . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Li Y, Hollingworth P, Moore P . Genetic association of the APP binding protein 2 gene (APBB2) with late onset Alzheimer disease . Hum. Mutat. . 25 . 3 . 270–7 . 2006 . 15714520 . 10.1002/humu.20138 . 28343972 . etal. free .
• Lange A, Thon L, Mathieu S, Adam D . The apoptosis inhibitory domain of FE65-like protein 1 regulates both apoptotic and caspase-independent programmed cell death mediated by tumor necrosis factor . Biochem. Biophys. Res. Commun. . 335 . 2 . 575–83 . 2005 . 16083851 . 10.1016/j.bbrc.2005.07.125 .
• Rual JF, Venkatesan K, Hao T . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 . etal.
• Hong Q, Hsu LJ, Schultz L . Zfra affects TNF-mediated cell death by interacting with death domain protein TRADD and negatively regulates the activation of NF-κB, JNK1, p53 and WOX1 during stress response . BMC Mol. Biol. . 8. 50 . 2007 . 17567906 . 10.1186/1471-2199-8-50 . 1904229 . etal . free .

Notes and References

1. McLoughlin DM, Miller CC . The intracellular cytoplasmic domain of the Alzheimer's disease amyloid precursor protein interacts with phosphotyrosine-binding domain proteins in the yeast two-hybrid system . FEBS Lett . 397 . 2–3 . 197–200 . Jan 1997 . 8955346 . 10.1016/S0014-5793(96)01128-3 . free .
2. Blanco G, Irving NG, Brown SD, Miller CC, McLoughlin DM . Mapping of the human and murine X11-like genes (APBA2 and apba2), the murine Fe65 gene (Apbb1), and the human Fe65-like gene (APBB2): genes encoding phosphotyrosine-binding domain proteins that interact with the Alzheimer's disease amyloid precursor protein . Mamm Genome . 9 . 6 . 473–5 . Jun 1998 . 9585438 . 10.1007/s003359900800. 31066473 .
3. Web site: Entrez Gene: APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 (Fe65-like).