APBB1IP explained

Amyloid beta A4 precursor protein-binding family B member 1-interacting protein (APBB1IP), also known as APBB1-interacting protein 1 or Rap1-GTP-interacting adapter molecule (RIAM) is a protein that in humans is encoded by the APBB1IP gene.^{[1] [2] [3]}

Further reading

• Lee HS, Lim CJ, Puzon-McLaughlin W . RIAM activates integrins by linking talin to ras GTPase membrane-targeting sequences. . J. Biol. Chem. . 284 . 8 . 5119–27 . 2009 . 19098287 . 10.1074/jbc.M807117200 . 2643525. etal. free .
• Ermekova KS, Zambrano N, Linn H . The WW domain of neural protein FE65 interacts with proline-rich motifs in Mena, the mammalian homolog of Drosophila enabled. . J. Biol. Chem. . 272 . 52 . 32869–77 . 1997 . 9407065 . 10.1074/jbc.272.52.32869. etal. free .
• Rose JE, Behm FM, Drgon T . Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. . Mol. Med. . 16 . 7–8 . 247–53 . 2010. 20379614 . 10.2119/molmed.2009.00159 . 2896464. etal.
• Morgan AR, Turic D, Jehu L . Association studies of 23 positional/functional candidate genes on chromosome 10 in late-onset Alzheimer's disease. . Am. J. Med. Genet. B Neuropsychiatr. Genet. . 144B . 6 . 762–70 . 2007 . 17373700 . 10.1002/ajmg.b.30509 . 26081707 . etal.
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928. etal.
• Jenzora A, Behrendt B, Small JV . PREL1 provides a link from Ras signalling to the actin cytoskeleton via Ena/VASP proteins. . FEBS Lett. . 579 . 2 . 455–63 . 2005 . 15642358 . 10.1016/j.febslet.2004.10.110 . 25677449 . etal. free .
• Grupe A, Li Y, Rowland C . A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. . Am. J. Hum. Genet. . 78 . 1 . 78–88 . 2006 . 16385451 . 10.1086/498851 . 1380225. etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2002 . 12477932 . 10.1073/pnas.242603899 . 139241. 2002PNAS...9916899M . etal. free .
• Patsoukis N, Lafuente EM, Meraner P . RIAM regulates the cytoskeletal distribution and activation of PLC-gamma1 in T cells. . Sci Signal . 2 . 99 . ra79 . 2009 . 19952372 . 10.1126/scisignal.2000409 . 2908902. etal.
• Deloukas P, Earthrowl ME, Grafham DV . The DNA sequence and comparative analysis of human chromosome 10. . Nature . 429 . 6990 . 375–81 . 2004 . 15164054 . 10.1038/nature02462 . 2004Natur.429..375D . etal. free .
• Linkermann A, Gelhaus C, Lettau M . Identification of interaction partners for individual SH3 domains of Fas ligand associated members of the PCH protein family in T lymphocytes. . Biochim. Biophys. Acta . 1794 . 2 . 168–76 . 2009 . 19041431 . 10.1016/j.bbapap.2008.10.013 . etal.
• Defilippi P, Di Stefano P, Cabodi S . p130Cas: a versatile scaffold in signaling networks. . Trends Cell Biol. . 16 . 5 . 257–63 . 2006 . 16581250 . 10.1016/j.tcb.2006.03.003 .
• Shattil SJ . Integrins and Src: dynamic duo of adhesion signaling. . Trends Cell Biol. . 15 . 8 . 399–403 . 2005 . 16005629 . 10.1016/j.tcb.2005.06.005 .

Notes and References

1. Web site: Entrez Gene: amyloid beta (A4) precursor protein-binding.
2. Inagaki T, Suzuki S, Miyamoto T, Takeda T, Yamashita K, Komatsu A, Yamauchi K, Hashizume K . The retinoic acid-responsive proline-rich protein is identified in promyeloleukemic HL-60 cells . J. Biol. Chem. . 278 . 51 . 51685–92 . December 2003 . 14530287 . 10.1074/jbc.M308016200 . free .
3. Lafuente EM, van Puijenbroek AA, Krause M, Carman CV, Freeman GJ, Berezovskaya A, Constantine E, Springer TA, Gertler FB, Boussiotis VA . RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion . Dev. Cell . 7 . 4 . 585–95 . October 2004 . 15469846 . 10.1016/j.devcel.2004.07.021 . 1721.1/83508 . free .