APBA3 explained

Amyloid beta A4 precursor protein-binding family A member 3 is a protein that in humans is encoded by the APBA3 gene.^{[1] [2]}

Function

The protein encoded by this gene is a member of the X11 protein family. It is an adapter protein that interacts with the Alzheimer's disease amyloid precursor protein. This gene product is believed to be involved in signal transduction processes. This gene is a candidate gene for Alzheimer's disease.

Interactions

APBA3 has been shown to interact with Amyloid precursor protein.^[3]

Further reading

• Kuriyan J, Cowburn D . Modular peptide recognition domains in eukaryotic signaling . Annual Review of Biophysics and Biomolecular Structure . 26 . 259–88 . 1997 . 9241420 . 10.1146/annurev.biophys.26.1.259 .
• Morishima-Kawashima M, Ihara Y . [Recent advances in Alzheimer's disease] . Seikagaku . 73 . 11 . 1297–307 . 2002 . 11831025 .
• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery . Genome Res. . 6 . 9 . 791–806 . 1997 . 8889548 . 10.1101/gr.6.9.791 . free .
• Okamoto M, Südhof TC . Mint 3: a ubiquitous mint isoform that does not bind to munc18-1 or -2 . Eur. J. Cell Biol. . 77 . 3 . 161–5 . 1999 . 9860131 . 10.1016/s0171-9335(98)80103-9 .
• Tanahashi H, Tabira T . Genomic organization of the human X11L2 gene (APBA3), a third member of the X11 protein family interacting with Alzheimer's beta-amyloid precursor protein . NeuroReport . 10 . 12 . 2575–8 . 1999 . 10574372 . 10.1097/00001756-199908200-00025 .
• Okamoto M, Nakajima Y, Matsuyama T, Sugita M . Amyloid precursor protein associates independently and collaboratively with PTB and PDZ domains of mint on vesicles and at cell membrane . Neuroscience . 104 . 3 . 653–65 . 2001 . 11440799 . 10.1016/S0306-4522(01)00124-5 . 39280897 .
• Wang P, Wang X, Pei D . Mint-3 regulates the retrieval of the internalized membrane-type matrix metalloproteinase, MT5-MMP, to the plasma membrane by binding to its carboxyl end motif EWV . J. Biol. Chem. . 279 . 19 . 20461–70 . 2004 . 14990567 . 10.1074/jbc.M400264200 . free .
• Malmberg EK, Andersson CX, Gentzsch M, Chen JH, Mengos A, Cui L, Hansson GC, Riordan JR . Bcr (breakpoint cluster region) protein binds to PDZ-domains of scaffold protein PDZK1 and vesicle coat protein Mint3 . J. Cell Sci. . 117 . Pt 23 . 5535–41 . 2005 . 15494376 . 10.1242/jcs.01472 . free .

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Amyloid-beta A4 precursor protein-binding family A member 3 (APBA3)

Notes and References

1. Tanahashi H, Tabira T . X11L2, a new member of the X11 protein family, interacts with Alzheimer's beta-amyloid precursor protein . Biochem Biophys Res Commun . 255 . 3 . 663–7 . Apr 1999 . 10049767 . 10.1006/bbrc.1999.0265 .
2. Web site: Entrez Gene: APBA3 amyloid beta (A4) precursor protein-binding, family A, member 3 (X11-like 2).
3. Biederer T, Cao X, Südhof TC, Liu X . Regulation of APP-dependent transcription complexes by Mint/X11s: differential functions of Mint isoforms . J. Neurosci. . 22 . 17 . 7340–51 . Sep 2002 . 12196555 . 10.1523/JNEUROSCI.22-17-07340.2002. 6757996 . free .