NECAB3 explained

N-terminal EF-hand calcium-binding protein 3 is a protein that in humans is encoded by the NECAB3 gene.^{[1] [2]}

The protein encoded by this gene interacts with the amino-terminal domain of the amyloid beta A4 precursor protein-binding family A member 2 (APBA2), inhibits the association of APBA2 with amyloid precursor protein through a non-competitive mechanism, and abolishes the suppression of beta-amyloid production by APBA2. This protein, together with APBA2, may play an important role in the regulatory system of amyloid precursor protein metabolism and beta-amyloid generation. This gene consists of at least 13 exons and its alternative splicing generates at least 2 transcript variants.

See also

• N-terminal
• EF-hand

Further reading

• Büssow K, Cahill D, Nietfeld W . A method for global protein expression and antibody screening on high-density filters of an arrayed cDNA library. . Nucleic Acids Res. . 26 . 21 . 5007–8 . 1998 . 9776767 . 10.1093/nar/26.21.5007 . 147919 . etal.
• Sugita S, Südhof TC . Specificity of Ca2+-dependent protein interactions mediated by the C2A domains of synaptotagmins. . Biochemistry . 39 . 11 . 2940–9 . 2000 . 10715114 . 10.1021/bi9920984 .
• Deloukas P, Matthews LH, Ashurst J . The DNA sequence and comparative analysis of human chromosome 20. . Nature . 414 . 6866 . 865–71 . 2002 . 11780052 . 10.1038/414865a . 2001Natur.414..865D . etal. free .
• Sugita S, Ho A, Südhof TC . NECABs: a family of neuronal Ca(2+)-binding proteins with an unusual domain structure and a restricted expression pattern. . Neuroscience . 112 . 1 . 51–63 . 2002 . 12044471 . 10.1016/S0306-4522(02)00063-5 . 18740496 .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Sumioka A, Imoto S, Martins RN . XB51 isoforms mediate Alzheimer's beta-amyloid peptide production by X11L (X11-like protein)-dependent and -independent mechanisms. . Biochem. J. . 374 . Pt 1 . 261–8 . 2003 . 12780348 . 10.1042/BJ20030489 . 1223589 . etal.
• Yoo JC, Chang JR, Kim SH . NIP1/XB51/NECAB3 is a potential substrate of Nek2, suggesting specific roles of Nek2 in Golgi. . Exp. Cell Res. . 292 . 2 . 393–402 . 2004 . 14697346 . 10.1016/j.yexcr.2003.09.025 . etal.
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.

Notes and References

1. Lee DS, Tomita S, Kirino Y, Suzuki T . Regulation of X11L-dependent amyloid precursor protein metabolism by XB51, a novel X11L-binding protein . J Biol Chem . 275 . 30 . 23134–8 . Aug 2000 . 10833507 . 10.1074/jbc.C000302200 . free .
2. Web site: Entrez Gene: APBA2BP amyloid beta (A4) precursor protein-binding, family A, member 2 binding protein.