AP1B1 explained

AP-1 complex subunit beta-1 is a protein that in humans is encoded by the AP1B1 gene.^{[1] [2] [3]}

Adaptor protein complex 1 is found at the cytoplasmic face of coated vesicles located at the Golgi complex, where it mediates both the recruitment of clathrin to the membrane and the recognition of sorting signals within the cytosolic tails of transmembrane receptors. This complex is a heterotetramer composed of two large, one medium, and one small adaptin subunit. The protein encoded by this gene serves as one of the large subunits of this complex and is a member of the adaptin protein family. This gene is a candidate meningioma gene. Two transcript variants encoding different isoforms have been found for this gene, and variants utilizing alternative polyadenylation signals exist.^[3]

Interactions

AP1B1 has been shown to interact with KIF13A^[4] and AP1G1.^{[5] [6] [7]}

Further reading

• Kirchhausen T . Clathrin. . Annu. Rev. Biochem. . 69 . 699–727 . 2000 . 10966473 . 10.1146/annurev.biochem.69.1.699 .
• Geyer M, Fackler OT, Peterlin BM . Structure--function relationships in HIV-1 Nef. . EMBO Rep. . 2 . 7 . 580–5 . 2001 . 11463741 . 10.1093/embo-reports/kve141 . 1083955 .
• Bénichou S, Benmerah A . [The HIV nef and the Kaposi-sarcoma-associated virus K3/K5 proteins: "parasites"of the endocytosis pathway] . Med Sci (Paris) . 19 . 1 . 100–6 . 2003 . 12836198 . 10.1051/medsci/2003191100. free .
• Lim DS, Kirsch DG, Canman CE . ATM binds to beta-adaptin in cytoplasmic vesicles. . Proc. Natl. Acad. Sci. U.S.A. . 95 . 17 . 10146–51 . 1998 . 9707615 . 10.1073/pnas.95.17.10146 . 21476 . 1998PNAS...9510146L . etal. free .
• Takatsu H, Sakurai M, Shin HW . Identification and characterization of novel clathrin adaptor-related proteins. . J. Biol. Chem. . 273 . 38 . 24693–700 . 1998 . 9733768 . 10.1074/jbc.273.38.24693 . etal. free .
• Craig HM, Pandori MW, Guatelli JC . Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivity. . Proc. Natl. Acad. Sci. U.S.A. . 95 . 19 . 11229–34 . 1998 . 9736718 . 10.1073/pnas.95.19.11229 . 21624 . 1998PNAS...9511229C . free .
• Bresnahan PA, Yonemoto W, Ferrell S . A dileucine motif in HIV-1 Nef acts as an internalization signal for CD4 downregulation and binds the AP-1 clathrin adaptor. . Curr. Biol. . 8 . 22 . 1235–8 . 1999 . 9811606 . 10.1016/S0960-9822(07)00517-9 . etal. free .
• Greenberg M, DeTulleo L, Rapoport I . A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for downregulation of CD4. . Curr. Biol. . 8 . 22 . 1239–42 . 1999 . 9811611 . 10.1016/S0960-9822(07)00518-0 . etal. free .
• Laporte SA, Oakley RH, Zhang J . The beta2-adrenergic receptor/betaarrestin complex recruits the clathrin adaptor AP-2 during endocytosis. . Proc. Natl. Acad. Sci. U.S.A. . 96 . 7 . 3712–7 . 1999 . 10097102 . 10.1073/pnas.96.7.3712 . 22359 . 1999PNAS...96.3712L . etal. free .
• Fölsch H, Ohno H, Bonifacino JS, Mellman I . A novel clathrin adaptor complex mediates basolateral targeting in polarized epithelial cells. . Cell . 99 . 2 . 189–98 . 1999 . 10535737 . 10.1016/S0092-8674(00)81650-5 . free .
• Kim ST, Lim DS, Canman CE, Kastan MB . Substrate specificities and identification of putative substrates of ATM kinase family members. . J. Biol. Chem. . 274 . 53 . 37538–43 . 2000 . 10608806 . 10.1074/jbc.274.53.37538 . free .
• Lai MM, Luo HR, Burnett PE . The calcineurin-binding protein cain is a negative regulator of synaptic vesicle endocytosis. . J. Biol. Chem. . 275 . 44 . 34017–20 . 2000 . 10931822 . 10.1074/jbc.C000429200 . etal. free .
• Nakagawa T, Setou M, Seog D . A novel motor, KIF13A, transports mannose-6-phosphate receptor to plasma membrane through direct interaction with AP-1 complex. . Cell . 103 . 4 . 569–81 . 2001 . 11106728 . 10.1016/S0092-8674(00)00161-6 . etal. free .
• Takatsu H, Futatsumori M, Yoshino K . Similar subunit interactions contribute to assembly of clathrin adaptor complexes and COPI complex: analysis using yeast three-hybrid system. . Biochem. Biophys. Res. Commun. . 284 . 4 . 1083–9 . 2001 . 11409905 . 10.1006/bbrc.2001.5081 . etal.
• Doray B, Kornfeld S . Gamma subunit of the AP-1 adaptor complex binds clathrin: implications for cooperative binding in coated vesicle assembly. . Mol. Biol. Cell . 12 . 7 . 1925–35 . 2001 . 11451993 . 10.1091/mbc.12.7.1925. 55640 .
• Jardine H, MacNee W, Donaldson K, Rahman I . Molecular mechanism of transforming growth factor (TGF)-beta1-induced glutathione depletion in alveolar epithelial cells. Involvement of AP-1/ARE and Fra-1. . J. Biol. Chem. . 277 . 24 . 21158–66 . 2002 . 11912197 . 10.1074/jbc.M112145200 . free .

Notes and References

1. Peyrard M, Fransson I, Xie YG, Han FY, Ruttledge MH, Swahn S, Collins JE, Dunham I, Collins VP, Dumanski JP . Characterization of a new member of the human beta-adaptin gene family from chromosome 22q12, a candidate meningioma gene . Hum Mol Genet . 3 . 8 . 1393–9 . January 1995 . 7987321 . 10.1093/hmg/3.8.1393 .
2. Peyrard M, Pan HQ, Kedra D, Fransson I, Swahn S, Hartman K, Clifton SW, Roe BA, Dumanski JP . Structure of the promoter and genomic organization of the human beta'-adaptin gene (BAM22) from chromosome 22q12 . Genomics . 36 . 1 . 112–7 . February 1997 . 8812422 . 10.1006/geno.1996.0431 .
3. Web site: Entrez Gene: AP1B1 adaptor-related protein complex 1, beta 1 subunit.
4. Nakagawa . T . Setou M . Seog D . Ogasawara K . Dohmae N . Takio K . Hirokawa N . November 2000 . A novel motor, KIF13A, transports mannose-6-phosphate receptor to plasma membrane through direct interaction with AP-1 complex . Cell . 103 . 4 . 569–81 . UNITED STATES. 0092-8674. 11106728 . 10.1016/S0092-8674(00)00161-6 . free .
5. Takatsu . H . Sakurai M . Shin H W . Murakami K . Nakayama K . September 1998 . Identification and characterization of novel clathrin adaptor-related proteins . J. Biol. Chem. . 273 . 38 . 24693–700 . UNITED STATES. 0021-9258. 9733768 . 10.1074/jbc.273.38.24693 . free .
6. Fölsch . H . Ohno H . Bonifacino J S . Mellman I . October 1999 . A novel clathrin adaptor complex mediates basolateral targeting in polarized epithelial cells . Cell . 99 . 2 . 189–98 . UNITED STATES. 0092-8674. 10535737 . 10.1016/S0092-8674(00)81650-5 . free .
7. Page . L J . Robinson M S . November 1995 . Targeting signals and subunit interactions in coated vesicle adaptor complexes . J. Cell Biol. . 131 . 3 . 619–30 . UNITED STATES. 0021-9525. 7593184 . 10.1083/jcb.131.3.619 . 2120623 .