Aldehyde oxidase 1 explained

Aldehyde oxidase 1 is an enzyme that in humans is encoded by the AOX1 gene.^{[1] [2]}

Aldehyde oxidase produces hydrogen peroxide and, under certain conditions, can catalyze the formation of superoxide.^[1]

Clinical significance

Aldehyde oxidase is a candidate gene for amyotrophic lateral sclerosis.^[2]

See also

• MOCOS

Further reading

• Wang AG, Yoon SY, Oh JH . Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. . Biochem. Biophys. Res. Commun. . 345 . 3 . 1022–32 . 2006 . 16712791 . 10.1016/j.bbrc.2006.04.175 . etal.
• Smith MA, Marinaki AM, Arenas M . Novel pharmacogenetic markers for treatment outcome in azathioprine-treated inflammatory bowel disease. . Aliment. Pharmacol. Ther. . 30 . 4 . 375–84 . 2009 . 19500084 . 10.1111/j.1365-2036.2009.04057.x . 1292701 . etal.
• Rose JE, Behm FM, Drgon T . Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. . Mol. Med. . 16 . 7–8 . 247–53 . 2010. 20379614 . 10.2119/molmed.2009.00159 . 2896464. etal.
• Sigruener A . Buechler C . Orsó E . Human aldehyde oxidase 1 interacts with ATP-binding cassette transporter-1 and modulates its activity in hepatocytes. . Horm. Metab. Res. . 39 . 11 . 781–9 . 2007 . 17992631 . 10.1055/s-2007-992129 . 28460089 . etal.
• Ichida K, Matsumura T, Sakuma R . Mutation of human molybdenum cofactor sulfurase gene is responsible for classical xanthinuria type II. . Biochem. Biophys. Res. Commun. . 282 . 5 . 1194–200 . 2001 . 11302742 . 10.1006/bbrc.2001.4719 . etal.
• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery. . Genome Res. . 6 . 9 . 791–806 . 1996 . 8889548 . 10.1101/gr.6.9.791. free .
• Alfaro JF, Joswig-Jones CA, Ouyang W . Purification and mechanism of human aldehyde oxidase expressed in Escherichia coli. . Drug Metab. Dispos. . 37 . 12 . 2393–8 . 2009 . 19741035 . 10.1124/dmd.109.029520 . 2784701. etal.
• Rodrigues AD . Comparison of levels of aldehyde oxidase with cytochrome P450 activities in human liver in vitro. . Biochem. Pharmacol. . 48 . 1 . 197–200 . 1994 . 8043023 . 10.1016/0006-2952(94)90240-2 .
• Wright RM, Vaitaitis GM, Wilson CM . cDNA cloning, characterization, and tissue-specific expression of human xanthine dehydrogenase/xanthine oxidase. . Proc. Natl. Acad. Sci. U.S.A. . 90 . 22 . 10690–4 . 1993 . 8248161 . 10.1073/pnas.90.22.10690 . 47843. 1993PNAS...9010690W . etal. free .
• Buechler C, Boettcher A, Bared SM . The carboxyterminus of the ATP-binding cassette transporter A1 interacts with a beta2-syntrophin/utrophin complex. . Biochem. Biophys. Res. Commun. . 293 . 2 . 759–65 . 2002 . 12054535 . 10.1016/S0006-291X(02)00303-0 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2002 . 12477932 . 10.1073/pnas.242603899 . 139241. 2002PNAS...9916899M . etal. free .
• Ross CJ, Katzov-Eckert H, Dubé MP . Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy. . Nat. Genet. . 41 . 12 . 1345–9 . 2009 . 19898482 . 10.1038/ng.478 . 21293339 . etal.

Notes and References

1. Web site: Entrez Gene: aldehyde oxidase 1.
2. Berger R, Mezey E, Clancy KP, Harta G, Wright RM, Repine JE, Brown RH, Brownstein M, Patterson D . Analysis of aldehyde oxidase and xanthine dehydrogenase/oxidase as possible candidate genes for autosomal recessive familial amyotrophic lateral sclerosis . Somat. Cell Mol. Genet. . 21 . 2 . 121–31 . March 1995 . 7570184 . 10.1007/BF02255787. 24691533 .