Annexin A9 Explained

Annexin A9 is a protein that in humans is encoded by the ANXA9 gene.^{[1] [2] [3]}

Function

The annexins are a family of calcium-dependent phospholipid-binding proteins. Members of the annexin family contain 4 internal repeat domains, each of which includes a type II calcium-binding site. The calcium-binding sites are required for annexins to aggregate and cooperatively bind anionic phospholipids and extracellular matrix proteins. This gene encodes a divergent member of the annexin protein family in which all four homologous type II calcium-binding sites in the conserved tetrad core contain amino acid substitutions that ablate their function. However, structural analysis suggests that the conserved putative ion channel formed by the tetrad core is intact.

Further reading

• Benz J, Hofmann A . Annexins: from structure to function . Biological Chemistry . 378 . 3–4 . 177–83 . 1997 . 9165068 .
• Nguyen VT, Ndoye A, Grando SA . Pemphigus vulgaris antibody identifies pemphaxin. A novel keratinocyte annexin-like molecule binding acetylcholine . The Journal of Biological Chemistry . 275 . 38 . 29466–76 . Sep 2000 . 10899159 . 10.1074/jbc.M003174200 . free .
• Goebeler V, Ruhe D, Gerke V, Rescher U . Atypical properties displayed by annexin A9, a novel member of the annexin family of Ca(2+) and lipid binding proteins . FEBS Letters . 546 . 2–3 . 359–64 . Jul 2003 . 12832069 . 10.1016/S0014-5793(03)00634-3 . 13433731 . free .
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP . Large-scale characterization of HeLa cell nuclear phosphoproteins . Proceedings of the National Academy of Sciences of the United States of America . 101 . 33 . 12130–5 . Aug 2004 . 15302935 . 514446 . 10.1073/pnas.0404720101 . 2004PNAS..10112130B . free .

Notes and References

1. Morgan RO, Fernandez MP . Expression profile and structural divergence of novel human annexin 31 . FEBS Letters . 434 . 3 . 300–4 . Sep 1998 . 9742942 . 10.1016/S0014-5793(98)00997-1 . 13751169 . free .
2. Morgan RO, Bell DW, Testa JR, Fernandez MP . Human annexin 31 genetic mapping and origin . Gene . 227 . 1 . 33–8 . Feb 1999 . 9931420 . 10.1016/S0378-1119(98)00597-6 .
3. Web site: Entrez Gene: ANXA9 annexin A9.