ANP32E explained

Acidic leucine-rich nuclear phosphoprotein 32 family member E is a protein that in humans is encoded by the ANP32E gene.^{[1] [2]} The ANP32E gene is located on chromosome 1q22. In mammalian cells, ANP32E has been shown to be an H2A.Z chaperone capable of promoting the removal of H2A.Z from chromatin.^[3] In brain tissue, ANP32E together with Cpd1 regulate protein phosphatase 2A activity at synapses during synaptogenesis^[4] and has been observed to form a complex with ANP32A and SET that stabilizes short-lived mRNAs containing AU-rich elements, as well as having acetyltransferase inhibitory activity (in a complex with SET) and having a role in chromatin remodeling and transcriptional regulation.^[5]

See also

• ANP32A, ANP32B, ANP32C, ANP32D

Further reading

• Matilla A, Radrizzani M . The Anp32 family of proteins containing leucine-rich repeats . Cerebellum . 4 . 1 . 7–18 . 2005 . 15895553 . 10.1080/14734220410019020 . 39153579 .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Hartley JL, Temple GF, Brasch MA . DNA cloning using in vitro site-specific recombination . Genome Res. . 10 . 11 . 1788–95 . 2001 . 11076863 . 10.1101/gr.143000 . 310948 .
• Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M . Nucleolar proteome dynamics . Nature . 433 . 7021 . 77–83 . 2005 . 15635413 . 10.1038/nature03207 . 2005Natur.433...77A . 4344740 .
• 11430900 . 2001 . Radrizzani . M. . Vilá-Ortiz . G. . Cafferata . E. G. . Di Tella . M. C. . González-Guerrico . A. . Perandones . C. . Pivetta . O. H. . Carminatti . H. . Idoyaga Vargas . V. P. . Santa-Coloma . T. A. . Differential expression of CPD1 during postnatal development in the mouse cerebellum . Brain Research . 907 . 1–2 . 162–174 . 10.1016/s0006-8993(01)02351-4 . 29698240 .
• 11188933 . 2000 . Radrizzani . M. . Brocardo . M. G. . Gonzalez Solveyra . C. . Bianchini . M. . Reyes . G. B. . Cafferata . E. G. . Vilá Ortiz . G. . Santa-Coloma . T. A. . Development of monoclonal oligobodies and chemically synthesized oligobodies . Medicina . 60 . Suppl 2 . 55–60 .

Notes and References

1. Jiang M, Ma Y, Ni X, Cao G, Ji C, Cheng H, Tang R, Xie Y, Mao Y . Molecular cloning and characterization of a novel human gene (ANP32E alias LANPL) from human fetal brain . Cytogenet Genome Res . 97 . 1–2 . 68–71 . Nov 2002 . 12438741 . 10.1159/000064058 . 30549428 .
2. Web site: Entrez Gene: ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E.
3. Obri A, Ouararhni K, Papin C, Diebold ML, Padmanabhan K, Marek M, Stoll I, Roy L, Reilly PT, Mak TW, Dimitrov S, Romier C, Hamiche A . ANP32E is a histone chaperone that removes H2A.Z from chromatin . Nature . 505 . 7485 . 648–53 . 2014 . 24463511 . 10.1038/nature12922 . 2014Natur.505..648O . 4406370 .
4. Costanzo RV, Vilá-Ortíz GJ, Perandones C, Carminatti H, Matilla A, Radrizzani M . Anp32e/Cpd1 regulates protein phosphatase 2A activity at synapses during synaptogenesis . Eur. J. Neurosci. . 23 . 2 . 309–24 . 2006 . 16420440 . 10.1111/j.1460-9568.2005.04555.x . 46587416 .
5. Santa-Coloma . T.A. . 2003 . Anp32e (Cpd1) and related protein phosphatase 2 inhibitors . Cerebellum . 2 . 4 . 310–20 . 10.1080/14734220310017212 . 14964690 . 21454532.