ANP32D explained

Acidic leucine-rich nuclear phosphoprotein 32 family member D is a protein that in humans is encoded by the ANP32D gene.^{[1] [2] [3]}

Phosphoprotein 32 (PP32) is a tumor suppressor that can inhibit several types of cancers, including prostate and breast cancers. The protein encoded by this gene is one of at least two proteins that are similar in amino acid sequence to PP32 and are part of the same acidic nuclear phosphoprotein gene family. However, unlike PP32, the encoded protein is tumorigenic. The tumor suppressor function of PP32 has been localized to a 25 amino acid region that is absent in the protein encoded by this gene. This gene does not contain introns.

See also

• ANP32A, ANP32B, ANP32C, ANP32E

Further reading

• Matilla A, Radrizzani M . The Anp32 family of proteins containing leucine-rich repeats . Cerebellum . 4 . 1 . 7–18 . 2005 . 15895553 . 10.1080/14734220410019020 . 39153579 .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Kadkol SS, El Naga GA, Brody JR . Expression of pp32 gene family members in breast cancer . Breast Cancer Res. Treat. . 68 . 1 . 65–73 . 2002 . 11678310 . 10.1023/A:1017919507109 . 11915912 . etal.
• Bai J, Brody JR, Kadkol SS, Pasternack GR . Tumor suppression and potentiation by manipulation of pp32 expression . Oncogene . 20 . 17 . 2153–60 . 2001 . 11360199 . 10.1038/sj.onc.1204294 . 8755931 . free .
• Kadkol SS, Brody JR, Pevsner J . Correction to "Modulation of oncogenic potential by alternative gene use in human prostate cancer" . Nat. Med. . 5 . 9 . 1087 . 1999. 10471270 . 10.1038/12530 . etal. free .

Notes and References

1. Kadkol SS, Brody JR, Pevsner J, Bai J, Pasternack GR . Modulation of oncogenic potential by alternative gene use in human prostate cancer . Nat Med . 5 . 3 . 275–9 . Apr 1999 . 10086381 . 10.1038/6488 . 24559649 .
2. Brody JR, Kadkol SS, Mahmoud MA, Rebel JM, Pasternack GR . Identification of sequences required for inhibition of oncogene-mediated transformation by pp32 . J Biol Chem . 274 . 29 . 20053–5 . Aug 1999 . 10400610 . 10.1074/jbc.274.29.20053 . free .
3. Web site: Entrez Gene: ANP32D acidic (leucine-rich) nuclear phosphoprotein 32 family, member D.