ANKRD23 explained

Ankyrin repeat domain-containing protein 23 is a protein that in humans is encoded by the ANKRD23 gene.^{[1] [2]}

This gene is a member of the muscle ankyrin repeat protein (MARP) family and encodes a protein with four tandem ankyrin-like repeats. The protein is localized to the nucleus, functioning as a transcriptional regulator. Expression of this protein is induced during recovery following starvation.^[2]

Interactions

ANKRD23 has been shown to interact with Titin^[3] and MYPN.^[3]

Further reading

• Hillier LW . Generation and annotation of the DNA sequences of human chromosomes 2 and 4 . Nature . 434 . 7034 . 724–31 . 2005 . 15815621 . 10.1038/nature03466 . cs2 . Graves TA . Fulton RS . 3 . Fulton . Lucinda A. . Pepin . Kymberlie H. . Minx . Patrick . Wagner-Mcpherson . Caryn . Layman . Dan . Wylie . Kristine . 2005Natur.434..724H. free .
• Gerhard DS . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . cs2 . Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Nagueh SF . Altered titin expression, myocardial stiffness, and left ventricular function in patients with dilated cardiomyopathy . Circulation . 110 . 2 . 155–62 . 2005 . 15238456 . 10.1161/01.CIR.0000135591.37759.AF . cs2 . Shah G . Wu Y . 3 . Torre-Amione . G . King . NM . Lahmers . S . Witt . CC . Becker . K . Labeit . S . free .
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . cs2 . Suzuki Y . Nishikawa T . 3 . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Miller MK . The muscle ankyrin repeat proteins: CARP, ankrd2/Arpp and DARP as a family of titin filament-based stress response molecules . J. Mol. Biol. . 333 . 5 . 951–64 . 2003 . 14583192 . 10.1016/j.jmb.2003.09.012 . cs2 . Bang ML . Witt CC . 3 . Labeit . Dietmar . Trombitas . Charles . Watanabe . Kaori . Granzier . Henk . McElhinny . Abigail S. . Gregorio . Carol C. .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . cs2 . Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M. free .
• Dias Neto E . Shotgun sequencing of the human transcriptome with ORF expressed sequence tags . Proc. Natl. Acad. Sci. U.S.A. . 97 . 7 . 3491–6 . 2000 . 10737800 . 10.1073/pnas.97.7.3491 . 16267 . cs2 . Correa RG . Verjovski-Almeida S . 3 . Briones . MR . Nagai . MA . Da Silva Jr . W . Zago . MA . Bordin . S . Costa . FF . 2000PNAS...97.3491D. free .

Notes and References

1. Ikeda K, Emoto N, Matsuo M, Yokoyama M . Molecular identification and characterization of a novel nuclear protein whose expression is up-regulated in insulin-resistant animals . J Biol Chem . 278 . 6 . 3514–20 . Feb 2003 . 12456686 . 10.1074/jbc.M204563200 . free .
2. Web site: Entrez Gene: ANKRD23 ankyrin repeat domain 23.
3. Miller . Melanie K . Bang Marie-Louise . Witt Christian C . Labeit Dietmar . Trombitas Charles . Watanabe Kaori . Granzier Henk . McElhinny Abigail S . Gregorio Carol C . Labeit Siegfried . Nov 2003 . The muscle ankyrin repeat proteins: CARP, ankrd2/Arpp and DARP as a family of titin filament-based stress response molecules . J. Mol. Biol. . 333 . 5 . 951–64 . 0022-2836. 14583192 . 10.1016/j.jmb.2003.09.012 .